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dc.contributor.authorAlvarenga, Lênio Souza [UNIFESP]
dc.contributor.authorMannis, Mark J. [UNIFESP]
dc.date.accessioned2018-06-18T11:23:30Z
dc.date.available2018-06-18T11:23:30Z
dc.date.issued2005-01-01
dc.identifierhttp://dx.doi.org/10.1016/S1542-0124(12)70121-0
dc.identifier.citationOcular Surface. New York: Ethis Communicatins, Inc, v. 3, n. 1, p. 41-58, 2005.
dc.identifier.issn1542-0124
dc.identifier.urihttp://repositorio.unifesp.br/11600/45060
dc.description.abstractRosacea is a common skin disease that frequently involves the eye. Although the pathogenesis of the disease remains undefined, recent findings suggest that an altered inflammatory response plays an important role in both cutaneous and ocular rosacea. Ocular manifestations include lid and ocular surface alterations. Chronic inflammation can lead to corneal vascularization, which may compromise vision. Treatment of ocular rosacea is aimed at preventing irritation of the ocular surface (e.g., lubricants, lid hygiene) and controlling inflammation with topical and systemic anti-inflammatory drugs. Systemic tetracyclines are the mainstay of treatment. These drugs act multifactorially by decreasing bacterial flora and the expression of matrix metalloproteinases, altering meibum secretion, inhibiting the production of bacterial lipases, and providing an immunomodulatory effect.en
dc.format.extent41-58
dc.language.isoeng
dc.publisherEthis Communicatins, Inc
dc.relation.ispartofOcular Surface
dc.rightsAcesso restrito
dc.subjectblepharitisen
dc.subjectDemodex folliculorumen
dc.subjectHelicobacter pylorien
dc.subjectkeratitisen
dc.subjectinflammatory disordersen
dc.subjectmetronidazoleen
dc.subjectocular inflammationen
dc.subjectocular rosaceaen
dc.subjectocular surfaceen
dc.subjectrosaceaen
dc.subjecttearsen
dc.subjecttetracyclinesen
dc.titleOcular rosaceaen
dc.typeResenha
dc.contributor.institutionUniv Calif Davis
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUniv Calif Davis, Dept Ophthalmol, Davis, CA 95616 USA
dc.description.affiliationUniv Fed Sao Paulo, Dept Ophthalmol, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Ophthalmol, Sao Paulo, Brazil
dc.identifier.doi10.1016/S1542-0124(12)70121-0
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000232533200005


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