Ocular rosacea

Date
2005-01-01Author
Alvarenga, Lênio Souza [UNIFESP]
Mannis, Mark J. [UNIFESP]
Type
ResenhaISSN
1542-0124Is part of
Ocular SurfaceDOI
10.1016/S1542-0124(12)70121-0Metadata
Show full item recordAbstract
Rosacea is a common skin disease that frequently involves the eye. Although the pathogenesis of the disease remains undefined, recent findings suggest that an altered inflammatory response plays an important role in both cutaneous and ocular rosacea. Ocular manifestations include lid and ocular surface alterations. Chronic inflammation can lead to corneal vascularization, which may compromise vision. Treatment of ocular rosacea is aimed at preventing irritation of the ocular surface (e.g., lubricants, lid hygiene) and controlling inflammation with topical and systemic anti-inflammatory drugs. Systemic tetracyclines are the mainstay of treatment. These drugs act multifactorially by decreasing bacterial flora and the expression of matrix metalloproteinases, altering meibum secretion, inhibiting the production of bacterial lipases, and providing an immunomodulatory effect.
Citation
Ocular Surface. New York: Ethis Communicatins, Inc, v. 3, n. 1, p. 41-58, 2005.Keywords
blepharitisDemodex folliculorum
Helicobacter pylori
keratitis
inflammatory disorders
metronidazole
ocular inflammation
ocular rosacea
ocular surface
rosacea
tears
tetracyclines
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