Ocular rosacea

Author Alvarenga, Lênio Souza Autor UNIFESP Google Scholar
Mannis, Mark J. Autor UNIFESP Google Scholar
Institution Univ Calif Davis
Universidade Federal de São Paulo (UNIFESP)
Abstract Rosacea is a common skin disease that frequently involves the eye. Although the pathogenesis of the disease remains undefined, recent findings suggest that an altered inflammatory response plays an important role in both cutaneous and ocular rosacea. Ocular manifestations include lid and ocular surface alterations. Chronic inflammation can lead to corneal vascularization, which may compromise vision. Treatment of ocular rosacea is aimed at preventing irritation of the ocular surface (e.g., lubricants, lid hygiene) and controlling inflammation with topical and systemic anti-inflammatory drugs. Systemic tetracyclines are the mainstay of treatment. These drugs act multifactorially by decreasing bacterial flora and the expression of matrix metalloproteinases, altering meibum secretion, inhibiting the production of bacterial lipases, and providing an immunomodulatory effect.
Keywords blepharitis
Demodex folliculorum
Helicobacter pylori
keratitis
inflammatory disorders
metronidazole
ocular inflammation
ocular rosacea
ocular surface
rosacea
tears
tetracyclines
Language English
Date 2005-01-01
Published in Ocular Surface. New York: Ethis Communicatins, Inc, v. 3, n. 1, p. 41-58, 2005.
ISSN 1542-0124 (Sherpa/Romeo, impact factor)
Publisher Ethis Communicatins, Inc
Extent 41-58
Origin http://dx.doi.org/10.1016/S1542-0124(12)70121-0
Access rights Closed access
Type Review
Web of Science ID WOS:000232533200005
URI http://repositorio.unifesp.br/11600/45060

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