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dc.contributor.authorMourão-Júnior, Carlos Alberto [UNIFESP]
dc.contributor.authorSchmidt, Sergio Luis
dc.contributor.authorManhaes, Alex Christian
dc.identifier.citationNeuroendocrinology Letters. Stockholm: Maghira & Maas Publications, v. 24, n. 6, p. 459-462, 2003.
dc.description.abstractOBJECTIVES: Approximately 20% of BALB/cCF mice are born with partial or total absence of the corpus callosum. Here, we analyzed testosterone and free thyroxin blood levels in adult male mice of this strain in order to see if these hormones are related to the incidence of callosal defects.METHODS: Blood collected from the axillary blood vessels of 12 normal and 10 acallosal deeply anesthetized adult male mice was used in order to determine testosterone and free thyroxin levels through chemiluminescence (IMMULITE, Diagnostics Products Corporation, USA).RESULTS: No significant difference (one-way ANOVA: F = 0.11, df = 1, p > 0.10) was found between normal ((X) over bar = 1.95, SD = 0.62) and acallosal ((X) over bar = 1.86, SD = 0.62) mice for free thyroxin level. On the other hand, in those mice that had detectable testosterone levels (above 0.2 ng/ml), a significant difference was found (t = 2.8, df = 6.06, p = 0.03): normal mice (n = 7, (X) over bar = 8.73, SD = 7.64) had a higher level than acallosal mice (n = 4, (X) over bar = 0.62, SD = 0.41).CONCLUSIONS: The present results indicate that the incidence of callosal agenesis is not related to free thyroxin levels in the blood of adult BALB/cCF mice. On the other hand, in spite of the fact that low testosterone levels seems to be frequent in male mice of this strain, acallosal mice tend to have lower levels of this hormone than normal mice.en
dc.publisherMaghira & Maas Publications
dc.relation.ispartofNeuroendocrinology Letters
dc.rightsAcesso aberto
dc.subjectcorpus callosumen
dc.titleTestosterone and free thyroxin blood in congenitally acallosal male BALB/cCF miceen
dc.contributor.institutionUniversidade do Estado do Rio de Janeiro (UERJ)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUniv Estado Rio De Janeiro, IBRAG, Lab Neurofisiol, Dept Ciencias Fisiol, Rio De Janeiro, RJ, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Programa Pos Grad Endocrinol, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Programa Pos Grad Endocrinol, Sao Paulo, Brazil
dc.description.sourceWeb of Science

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