Effect of ganglioside (GM1) on memory in senescent rats
Silva, Regina Helena da [UNIFESP]
Felicio, Luciano Freitas
Nasello, Antonia Gladys
Vital, Maria Aparecida Barbato Frazao [UNIFESP]
Frussa-Filho, Roberto [UNIFESP]
Is part ofNeurobiology Of Aging
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Monosialoganglioside GM1 (GM1) has been found to alleviate genetic and lesion-induced memory deficits. The purpose of this study was to investigate the effects of 7-day treatment with GM1 (50 mg/kg IF) on acquisition and retention performance of senescent rats in a passive avoidance situation. Saline-treated old rats showed a decreased performance in acquisition and retention tests as compared to saline-treated adult rats. GM1 improved both acquisition and retention performance of old animals, and there was no significant difference between GM1-treated old rats and saline-treated adult rats. These data suggest that GM1 treatment can improve memory deficits in intact senescent animals.
CitationNeurobiology Of Aging. New York: Elsevier Science Inc, v. 17, n. 4, p. 583-586, 1996.
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