Anti-trypanosomal Phenolic Derivatives from Baccharis uncinella

Anti-trypanosomal Phenolic Derivatives from Baccharis uncinella

Author Grecco, Simone dos Santos Autor UNIFESP Google Scholar
Felix, Maria Julia Pereira Autor UNIFESP Google Scholar
Lago, Joao Henrique Ghilardi Autor UNIFESP Google Scholar
Pinto, Erika Gracielle Google Scholar
Tempone, André Gustavo Google Scholar
Romoff, Paulete Google Scholar
Ferreira, Marcelo José Pena Google Scholar
Sartorelli, Patricia Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do ABC (UFABC)
Adolfo Lutz Inst
Universidade de São Paulo (USP)
Univ Presbiteriana Mackenzie
Abstract Bioassay-guided fractionation of the EtOH extract of the aerial parts of Baccharis uncinella C. DC. (Asteraceae) led to identification of two cinnamic acid derivatives (caffeic and ferulic acids), two flavones (hispidulin and pectolinaringenin) and a mixture of three chlorogenic acids (3,4-, 3,5- and 4,5-O-dicaffeoylquinic acids), which displayed in vitro anti-trypanosomal activity. Pectolinaringenin, hispidulin and caffeic acid showed activity against trypomastigotes of Trypanosoma cruzi, exhibiting 50% inhibitory concentration (IC50) values of 52, 81 and 56 mu g/mL, respectively, while the chlorogenic acid mixture showed an IC50 value of 61 mu g/mL. The flavonoids and cinnamic acid derivatives were evaluated for cytotoxicity against NCTC cells resulting in a 50% cytotoxic concentration (CC50) ranging from 33.82 to 129.1 mu g/mL while the chlorogenic acids did not display cytotoxicity (CC50 >150 mu g/mL). This is the first report of anti-trypanosomal activity of compounds from B. uncinella.
Keywords Baccharis uncinella
Asteraceae
Antitrypanosomal
Flavanones
Chlorogenic acids
Cinnamic acid derivatives
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number FAPESP: 2011/51739-0
CNPq: 470853/2012-3
Date 2014-02-01
Published in Natural Product Communications. Westerville: Natural Products Inc, v. 9, n. 2, p. 171-173, 2014.
ISSN 1934-578X (Sherpa/Romeo, impact factor)
Publisher Natural Products Inc
Extent 171-173
Access rights Closed access
Type Article
Web of Science ID WOS:000331666900010
URI http://repositorio.unifesp.br/11600/44970

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