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dc.contributor.authorBor-Seng-Shu, Edson
dc.contributor.authorFelício, André Carvalho [UNIFESP]
dc.contributor.authorBraga-Neto, Pedro [UNIFESP]
dc.contributor.authorBatista, Ilza Rosa [UNIFESP]
dc.contributor.authorPaiva, Wellingson Silva
dc.contributor.authorAndrade, Daniel Ciampi de
dc.contributor.authorTeixeira, Manoel Jacobsen
dc.contributor.authorFranco de Andrade, Luiz Augusto
dc.contributor.authorBarsottini, Orlando Graziani Povoas [UNIFESP]
dc.contributor.authorShih, Ming Chi
dc.contributor.authorBressan, Rodrigo Affonseca [UNIFESP]
dc.contributor.authorFerraz, Henrique Ballalai [UNIFESP]
dc.identifier.citationMedical Science Monitor. Smithtown: Int Scientific Literature, Inc, v. 20, p. 1413-1418, 2014.
dc.description.abstractBackground: Although the decrease in striatal dopamine transporter (DAT) density has been described in North American, European, and Asian Parkinson's disease (PD) patients, studies on this issue are required in the rest of the world. This study examined the diagnostic utility of DAT imaging in Brazilian PD patients.Material/Methods: Twenty PD patients (13 males, 7 females, median age: 62 years, median age at disease onset: 56 years, median disease duration: 5 years, and median UPDRS-III score: 29) and 9 age-and sex-matched healthy subjects underwent single-photon emission computerized tomography (SPECT) using Tc-99m-TRODAT-1.Results: PD patients showed a significant decrease in the striatum, caudate nucleus, and putamen DAT densities compared with data from healthy subjects. Striatal Tc-99m-TRODAT-1 bindings had the highest diagnostic accuracy compared to those estimates from caudate nucleus and putamen. For the diagnosis of PD, a striatal Tc-99m-TRODAT-1 binding cut-off value of 0.90 was associated with a sensitivity of 100% and a specificity of 89%. There was no significant difference between striatal Tc-99m-TRODAT-1 binding values provided by different readers, contrary to Tc-99m-TRODAT-1 binding estimates in the caudate nucleus.Conclusions: Striatal DAT imaging using Tc-99m-TRODAT-1 can be considered a marker for differentiating PD patients from healthy individuals, with a good interobserver reproducibility.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.publisherInt Scientific Literature, Inc
dc.relation.ispartofMedical Science Monitor
dc.rightsAcesso aberto
dc.subjectMolecular Imagingen
dc.subjectParkinson Disease - radionuclide imagingen
dc.subjectTomography, Emission-Computed, Single-Photonen
dc.titleDopamine Transporter Imaging Using Tc-99m-TRODAT-1 SPECT in Parkinson's Diseaseen
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionHosp Israelita Albert Einstein
dc.description.affiliationUniv Sao Paulo, Sch Med, Hosp Clin, Dept Neurol Surg, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Neurol & Neurosurg, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Psychiat, Sao Paulo, Brazil
dc.description.affiliationHosp Israelita Albert Einstein, Dept Neurol, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Neurol & Neurosurg, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Psychiat, Sao Paulo, Brazil
dc.description.sourceWeb of Science

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