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dc.contributor.authorMurray, Christopher J. L.
dc.contributor.authorVos, Theo
dc.contributor.authorLozano, Rafael
dc.contributor.authorNaghavi, Mohsen
dc.contributor.authorFlaxman, Abraham D.
dc.contributor.authorMichaud, Catherine
dc.contributor.authorEzzati, Majid
dc.contributor.authorShibuya, Kenji
dc.contributor.authorSalomon, Joshua A.
dc.contributor.authorAbdalla, Safa
dc.contributor.authorAboyans, Victor
dc.contributor.authorAbraham, Jerry
dc.contributor.authorAckerman, Ilana
dc.contributor.authorAggarwal, Rakesh
dc.contributor.authorAhn, Stephanie Y.
dc.contributor.authorAli, Mohammed K.
dc.contributor.authorAlvarado, Miriam
dc.contributor.authorAnderson, H. Ross
dc.contributor.authorAnderson, Laurie M.
dc.contributor.authorAndrews, Kathryn G.
dc.contributor.authorAtkinson, Charles
dc.contributor.authorBaddour, Larry M.
dc.contributor.authorBahalim, Adil N.
dc.contributor.authorBarker-Collo, Suzanne
dc.contributor.authorBarrero, Lope H.
dc.contributor.authorBartels, David H.
dc.contributor.authorBasanez, Maria-Gloria
dc.contributor.authorBaxter, Amanda
dc.contributor.authorBell, Michelle L.
dc.contributor.authorBenjamin, Emelia J.
dc.contributor.authorBennett, Derrick
dc.contributor.authorBernabe, Eduardo
dc.contributor.authorBhalla, Kavi
dc.contributor.authorBhandari, Bishal
dc.contributor.authorBikbov, Boris
dc.contributor.authorBin Abdulhak, Aref
dc.contributor.authorBirbeck, Gretchen
dc.contributor.authorBlack, James A.
dc.contributor.authorBlencowe, Hannah
dc.contributor.authorBlore, Jed D.
dc.contributor.authorBlyth, Fiona
dc.contributor.authorBolliger, Ian
dc.contributor.authorBonaventure, Audrey
dc.contributor.authorBoufous, Soufi Ane
dc.contributor.authorBourne, Rupert
dc.contributor.authorBoussinesq, Michel
dc.contributor.authorBraithwaite, Tasanee
dc.contributor.authorBrayne, Carol
dc.contributor.authorBridgett, Lisa
dc.contributor.authorBrooker, Simon
dc.contributor.authorBrooks, Peter
dc.contributor.authorBrugha, Traolach S.
dc.contributor.authorBryan-Hancock, Claire
dc.contributor.authorBucello, Chiara
dc.contributor.authorBuchbinder, Rachelle
dc.contributor.authorBuckle, Geoffrey
dc.contributor.authorBudke, Christine M.
dc.contributor.authorBurch, Michael
dc.contributor.authorBurney, Peter
dc.contributor.authorBurstein, Roy
dc.contributor.authorCalabria, Bianca
dc.contributor.authorCampbell, Benjamin
dc.contributor.authorCanter, Charles E.
dc.contributor.authorCarabin, Helene
dc.contributor.authorCarapetis, Jonathan
dc.contributor.authorCarmona, Loreto
dc.contributor.authorCella, Claudia
dc.contributor.authorCharlson, Fiona
dc.contributor.authorChen, Honglei
dc.contributor.authorCheng, Andrew Tai-Ann
dc.contributor.authorChou, David
dc.contributor.authorChugh, Sumeet S.
dc.contributor.authorCoffeng, Luc E.
dc.contributor.authorColan, Steven D.
dc.contributor.authorColquhoun, Samantha
dc.contributor.authorColson, K. Ellicott
dc.contributor.authorCondon, John
dc.contributor.authorConnor, Myles D.
dc.contributor.authorCooper, Leslie T.
dc.contributor.authorCorriere, Matthew
dc.contributor.authorCortinovis, Monica
dc.contributor.authorDe Vaccaro, Karen Courville
dc.contributor.authorCouser, William
dc.contributor.authorCowie, Benjamin C.
dc.contributor.authorCriqui, Michael H.
dc.contributor.authorCross, Marita
dc.contributor.authorDabhadkar, Kaustubh C.
dc.contributor.authorDahiya, Manu
dc.contributor.authorDahodwala, Nabila
dc.contributor.authorDamsere-Derry, James
dc.contributor.authorDanaei, Goodarz
dc.contributor.authorDavis, Adrian
dc.contributor.authorDe Leo, Diego
dc.contributor.authorDegenhardt, Louisa
dc.contributor.authorDellavalle, Robert
dc.contributor.authorDelossantos, Allyne
dc.contributor.authorDenenberg, Julie
dc.contributor.authorDerrett, Sarah
dc.contributor.authorDes Jarlais, Don C.
dc.contributor.authorDharmaratne, Samath D.
dc.contributor.authorDherani, Mukesh
dc.contributor.authorDiaz-Torne, Cesar
dc.contributor.authorDolk, Helen
dc.contributor.authorDorsey, E. Ray
dc.contributor.authorDriscoll, Tim
dc.contributor.authorDuber, Herbert
dc.contributor.authorEbel, Beth
dc.contributor.authorEdmond, Karen
dc.contributor.authorElbaz, Alexis
dc.contributor.authorAli, Suad Eltahir
dc.contributor.authorErskine, Holly
dc.contributor.authorErwin, Patricia J.
dc.contributor.authorEspindola, Patricia
dc.contributor.authorEwoigbokhan, Stalin E.
dc.contributor.authorFarzadfar, Farshad
dc.contributor.authorFeigin, Valery
dc.contributor.authorFelson, David T.
dc.contributor.authorFerrari, Alize
dc.contributor.authorFerri, Cleusa P.
dc.contributor.authorFevre, Eric M.
dc.contributor.authorFinucane, Mariel M.
dc.contributor.authorFlaxman, Seth
dc.contributor.authorFlood, Louise
dc.contributor.authorForeman, Kyle
dc.contributor.authorForouzanfar, Mohammad H.
dc.contributor.authorFowkes, Francis Gerry R.
dc.contributor.authorFransen, Marlene
dc.contributor.authorFreeman, Michael K.
dc.contributor.authorGabbe, Belinda J.
dc.contributor.authorGabriel, Sherine E.
dc.contributor.authorGakidou, Emmanuela
dc.contributor.authorGanatra, Hammad A.
dc.contributor.authorGarcia, Bianca
dc.contributor.authorGaspari, Flavio
dc.contributor.authorGillum, Richard F.
dc.contributor.authorGmel, Gerhard
dc.contributor.authorGonzalez-Medina, Diego
dc.contributor.authorGosselin, Richard
dc.contributor.authorGrainger, Rebecca
dc.contributor.authorGrant, Bridget
dc.contributor.authorGroeger, Justina
dc.contributor.authorGuillemin, Francis
dc.contributor.authorGunnell, David
dc.contributor.authorGupta, Ramyani
dc.contributor.authorHaagsma, Juanita
dc.contributor.authorHagan, Holly
dc.contributor.authorHalasa, Yara A.
dc.contributor.authorHall, Wayne
dc.contributor.authorHaring, Diana
dc.contributor.authorMaria Haro, Josep
dc.contributor.authorHarrison, James E.
dc.contributor.authorHavmoeller, Rasmus
dc.contributor.authorHay, Roderick J.
dc.contributor.authorHigashi, Hideki
dc.contributor.authorHill, Catherine
dc.contributor.authorHoen, Bruno
dc.contributor.authorHoffman, Howard
dc.contributor.authorHotez, Peter J.
dc.contributor.authorHoy, Damian
dc.contributor.authorHuang, John J.
dc.contributor.authorIbeanusi, Sydney E.
dc.contributor.authorJacobsen, Kathryn H.
dc.contributor.authorJames, Spencer L.
dc.contributor.authorJarvis, Deborah
dc.contributor.authorJasrasaria, Rashmi
dc.contributor.authorJayaraman, Sudha
dc.contributor.authorJohns, Nicole
dc.contributor.authorJonas, Jost B.
dc.contributor.authorKarthikeyan, Ganesan
dc.contributor.authorKassebaum, Nicholas
dc.contributor.authorKawakami, Norito
dc.contributor.authorKeren, Andre
dc.contributor.authorKhoo, Jon-Paul
dc.contributor.authorKing, Charles H.
dc.contributor.authorKnowlton, Lisa Marie
dc.contributor.authorKobusingye, Olive
dc.contributor.authorKoranteng, Adofo
dc.contributor.authorKrishnamurthi, Rita
dc.contributor.authorLaden, Francine
dc.contributor.authorLalloo, Ratilal
dc.contributor.authorLaslett, Laura L.
dc.contributor.authorLathlean, Tim
dc.contributor.authorLeasher, Janet L.
dc.contributor.authorLee, Yong Yi
dc.contributor.authorLeigh, James
dc.contributor.authorLevinson, Daphna
dc.contributor.authorLim, Stephen S.
dc.contributor.authorLimb, Elizabeth
dc.contributor.authorLin, John Kent
dc.contributor.authorLipnick, Michael
dc.contributor.authorLipshultz, Steven E.
dc.contributor.authorLiu, Wei
dc.contributor.authorLoane, Maria
dc.contributor.authorOhno, Summer Lockett
dc.contributor.authorLyons, Ronan
dc.contributor.authorMabweijano, Jacqueline
dc.contributor.authorMacIntyre, Michael F.
dc.contributor.authorMalekzadeh, Reza
dc.contributor.authorMallinger, Leslie
dc.contributor.authorManivannan, Sivabalan
dc.contributor.authorMarcenes, Wagner
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dc.contributor.authorMarks, Guy B.
dc.contributor.authorMarks, Robin
dc.contributor.authorMatsumori, Akira
dc.contributor.authorMatzopoulos, Richard
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dc.contributor.authorMcDermott, Mary M.
dc.contributor.authorMcGill, Neil
dc.contributor.authorMcGrath, John
dc.contributor.authorElena Medina-Mora, Maria
dc.contributor.authorMeltzer, Michele
dc.contributor.authorMensah, George A.
dc.contributor.authorMerriman, Tony R.
dc.contributor.authorMeyer, Ana-Claire
dc.contributor.authorMiglioli, Valeria
dc.contributor.authorMiller, Matthew
dc.contributor.authorMiller, Ted R.
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dc.contributor.authorMock, Charles
dc.contributor.authorMocumbi, Ana Olga
dc.contributor.authorMoffitt, Terrie E.
dc.contributor.authorMokdad, Ali A.
dc.contributor.authorMonasta, Lorenzo
dc.contributor.authorMontico, Marcella
dc.contributor.authorMoradi-Lakeh, Maziar
dc.contributor.authorMoran, Andrew
dc.contributor.authorMorawska, Lidia
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dc.contributor.authorMwaniki, Michael K.
dc.contributor.authorNaidoo, Kovin
dc.contributor.authorNair, M. Nathan
dc.contributor.authorNaldi, Luigi
dc.contributor.authorNarayan, K. M. Venkat
dc.contributor.authorNelson, Paul K.
dc.contributor.authorNelson, Robert G.
dc.contributor.authorNevitt, Michael C.
dc.contributor.authorNewton, Charles R.
dc.contributor.authorNolte, Sandra
dc.contributor.authorNorman, Paul
dc.contributor.authorNorman, Rosana
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dc.contributor.authorO'Hanlon, Simon
dc.contributor.authorOlives, Casey
dc.contributor.authorOmer, Saad B.
dc.contributor.authorOrtblad, Katrina
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dc.contributor.authorPahari, Bishnu
dc.contributor.authorPandian, Jeyaraj Durai
dc.contributor.authorPanozo Rivero, Andrea
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dc.contributor.authorPerez-Ruiz, Fernando
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dc.contributor.authorPolinder, Suzanne
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dc.contributor.authorYeh, Pon-Hsiu
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dc.date.accessioned2018-06-18T10:54:46Z
dc.date.available2018-06-18T10:54:46Z
dc.date.issued2012-12-15
dc.identifierhttp://dx.doi.org/10.1016/S0140-6736(12)61689-4
dc.identifier.citationLancet. New York: Elsevier Science Inc, v. 380, n. 9859, p. 2197-2223, 2012.
dc.identifier.issn0140-6736
dc.identifier.urihttp://repositorio.unifesp.br/11600/44837
dc.description.abstractBackground Measuring disease and injury burden in populations requires a composite metric that captures both premature mortality and the prevalence and severity of ill-health. The 1990 Global Burden of Disease study proposed disability-adjusted life years (DALYs) to measure disease burden. No comprehensive update of disease burden worldwide incorporating a systematic reassessment of disease and injury-specific epidemiology has been done since the 1990 study. We aimed to calculate disease burden worldwide and for 21 regions for 1990, 2005, and 2010 with methods to enable meaningful comparisons over time.Methods We calculated DALYs as the sum of years of life lost (YLLs) and years lived with disability (YLDs). DALYs were calculated for 291 causes, 20 age groups, both sexes, and for 187 countries, and aggregated to regional and global estimates of disease burden for three points in time with strictly comparable definitions and methods. YLLs were calculated from age-sex-country-time-specific estimates of mortality by cause, with death by standardised lost life expectancy at each age. YLDs were calculated as prevalence of 1160 disabling sequelae, by age, sex, and cause, and weighted by new disability weights for each health state. Neither YLLs nor YLDs were age-weighted or discounted. Uncertainty around cause-specific DALYs was calculated incorporating uncertainty in levels of all-cause mortality, cause-specific mortality, prevalence, and disability weights.Findings Global DALYs remained stable from 1990 (2.503 billion) to 2010 (2.490 billion). Crude DALYs per 1000 decreased by 23% (472 per 1000 to 361 per 1000). An important shift has occurred in DALY composition with the contribution of deaths and disability among children (younger than 5 years of age) declining from 41% of global DALYs in 1990 to 25% in 2010. YLLs typically account for about half of disease burden in more developed regions (high-income Asia Pacific, western Europe, high-income North America, and Australasia), rising to over 80% of DALYs in sub-Saharan Africa. In 1990, 47% of DALYs worldwide were from communicable, maternal, neonatal, and nutritional disorders, 43% from non-communicable diseases, and 10% from injuries. By 2010, this had shifted to 35%, 54%, and 11%, respectively. Ischaemic heart disease was the leading cause of DALYs worldwide in 2010 (up from fourth rank in 1990, increasing by 29%), followed by lower respiratory infections (top rank in 1990; 44% decline in DALYs), stroke (fifth in 1990; 19% increase), diarrhoeal diseases (second in 1990; 51% decrease), and HIV/AIDS (33rd in 1990; 351% increase). Major depressive disorder increased from 15th to 11th rank (37% increase) and road injury from 12th to 10th rank (34% increase). Substantial heterogeneity exists in rankings of leading causes of disease burden among regions.Interpretation Global disease burden has continued to shift away from communicable to non-communicable diseases and from premature death to years lived with disability. In sub-Saharan Africa, however, many communicable, maternal, neonatal, and nutritional disorders remain the dominant causes of disease burden. The rising burden from mental and behavioural disorders, musculoskeletal disorders, and diabetes will impose new challenges on health systems. Regional heterogeneity highlights the importance of understanding local burden of disease and setting goals and targets for the post-2015 agenda taking such patterns into account. Because of improved definitions, methods, and data, these results for 1990 and 2010 supersede all previously published Global Burden of Disease results.en
dc.description.sponsorshipBerlin Heart Honoraria
dc.description.sponsorshipLundbeck
dc.description.sponsorshipMedtronic
dc.description.sponsorshipPrana Biotechnology
dc.description.sponsorshipSafework Australia
dc.description.sponsorshipAssurance-Maladie (CNAMTS) InVS
dc.description.sponsorshipInserm
dc.description.sponsorshipCHU de Nancy
dc.description.sponsorshipCHU de Nice
dc.description.sponsorshipConseil Regional de Lorraine
dc.description.sponsorshipSociete Francaise de Negma-Lerads
dc.description.sponsorshipPfizer
dc.description.sponsorshipPierre Fabre Medicaments
dc.description.sponsorshipSanofi-Afentis France
dc.description.sponsorshipSpanish Health Ministry
dc.description.sponsorshipHospital de Cruces Rheumatology Association
dc.description.sponsorshipNovartis
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipTakeda
dc.description.sponsorshipSavient
dc.description.sponsorshipArdea
dc.description.sponsorshipRegeneron
dc.description.sponsorshipAllergan
dc.description.sponsorshipURL pharmaceuticals
dc.description.sponsorship36 companies
dc.description.sponsorshipNational Institutes of Arthritis, Musculoskeletal and Skin Diseases (NIAMS)
dc.description.sponsorshipNational Institutes of Aging (NIA)
dc.description.sponsorshipNational Cancer Institute (NCI)
dc.description.sponsorshipAgency for Health Quality and Research Center for Education and Research on Therapeutics (CERTs)
dc.description.sponsorshipWellcome Trust
dc.description.sponsorshipDepartment of Health London for the National Health Service Information Centre
dc.description.sponsorshipUniversity of Leicester
dc.description.sponsorshipAustralian National Health and Medical Research Council (NHMRC)
dc.description.sponsorshipMonash University
dc.description.sponsorshipCabrini Health
dc.description.sponsorshipBUPA Foundation
dc.description.sponsorshipNIH
dc.description.sponsorshipNational Institute of Environmental Health Sciences
dc.description.sponsorshipAfrica Programme for Onchocerciasis Control (WHO/APOC)
dc.description.sponsorshipVictorian Infectious Diseases Reference Laboratory, Melbourne, Australia
dc.description.sponsorshipParkinson Council
dc.description.sponsorshipAustralian NHMRC
dc.description.sponsorshipUS Department of Veterans Affairs
dc.description.sponsorshipHealth Research Council of New Zealand
dc.description.sponsorshipUniversity of Otago
dc.description.sponsorshipNational Institute for Stroke and Applied Neurosciences
dc.description.sponsorshipAUT University
dc.description.sponsorshipNHMRC
dc.description.sponsorshipSwedish Research Council
dc.description.sponsorshipBill and Melinda Gates Foundation
dc.description.sponsorshipAustralian National Health and Medical Research Council
dc.description.sponsorshipWorld Health Organization
dc.description.sponsorshipWorld Mental Health Japan (WMH-J)
dc.description.sponsorshipJapan Ministry of Health, Labour, and Welfare
dc.description.sponsorshipAustralian Government
dc.description.sponsorshipNational Health and Medical Research Council of Australia
dc.description.sponsorshipArthritis Foundation of Australia
dc.description.sponsorshipTasmanian Community Fund
dc.description.sponsorshipMasonic Centenary Medical Research Foundation
dc.description.sponsorshipRoyal Hobart Hospital Research Foundation
dc.description.sponsorshipUniversity of Tasmania
dc.description.sponsorshipTehran University of Medical Sciences
dc.description.sponsorshipSouth African Medical Research Council Burden of Disease Research Unit
dc.description.sponsorshipUniversity of Cape Town School of Public Health and Family Medicine
dc.description.sponsorshipBrien Holden Vision Institute
dc.description.sponsorshipNational Drug and Alcohol Research Centre (UNSW, Australia)
dc.description.sponsorshipIntramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases
dc.description.sponsorshipBiostatistics, Epidemiologic and Bioinformatic Training in Environmental Health Training Grant
dc.description.sponsorshipFoundation for Alcohol Research and Education
dc.description.sponsorshipVictorian Department of Health
dc.description.sponsorshipBurke Global Health Fellowship
dc.description.sponsorshipHarold Amos Medical Faculty Development Award of the Robert Wood Johnson Foundation
dc.description.sponsorshipVanderbilt Clinical and Translational Scholars Award
dc.description.sponsorshipSpanish Society of Rheumatology (Sociedad Espanola de Reumatologia)
dc.description.sponsorshipEuropean Center for Injury Prevention, Universidad de Navarra
dc.description.sponsorshipDepartment of Health and Ageing
dc.description.sponsorshipCommonwealth Government of Australia
dc.description.sponsorshipInstitute of Bone and Joint Research (IBJR)
dc.description.sponsorshipUniversity of Sydney (USYD)
dc.description.sponsorshipWellcome Trust UK
dc.description.sponsorshipMedical Research Council UK
dc.description.sponsorshipAnthony Cerami and Ann Dunne Research Trust
dc.format.extent2197-2223
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofLancet
dc.rightsAcesso restrito
dc.titleDisability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010en
dc.typeArtigo
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
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dc.contributor.institutionUniv Penn
dc.contributor.institutionBldg & Rd Res Inst
dc.contributor.institutionMRC Hearing & Commun Grp
dc.contributor.institutionGriffith Univ
dc.contributor.institutionDenver VA Med Ctr
dc.contributor.institutionUniv Otago
dc.contributor.institutionBeth Israel Deaconess Med Ctr
dc.contributor.institutionUniv Peradeniya
dc.contributor.institutionUniv Liverpool
dc.contributor.institutionHosp Santa Creu & Sant Pau
dc.contributor.institutionUniv Ulster
dc.contributor.institutionFed Minist Hlth
dc.contributor.institutionHosp Maciel
dc.contributor.institutionEmerald Publ Hlth Consulting Serv Ltd
dc.contributor.institutionUniv Tehran Med Sci
dc.contributor.institutionAuckland Tech Univ
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionCarnegie Mellon Univ
dc.contributor.institutionJames Cook Univ
dc.contributor.institutionHoward Univ
dc.contributor.institutionAddict Info Switzerland
dc.contributor.institutionUniv Calif San Francisco
dc.contributor.institutionSuny Downstate Med Ctr
dc.contributor.institutionCtr Dis Control & Prevent
dc.contributor.institutionUniv Lorraine
dc.contributor.institutionUniv Bristol
dc.contributor.institutionNYU
dc.contributor.institutionBrandeis Univ
dc.contributor.institutionUniv Barcelona
dc.contributor.institutionKarolinska Univ Hosp
dc.contributor.institutionQueen Elizabeth Hosp
dc.contributor.institutionUniv Franche Comte
dc.contributor.institutionCtr Hosp Reg Univ Besancon
dc.contributor.institutionNIDCD
dc.contributor.institutionNIDDK
dc.contributor.institutionBaylor Coll Med
dc.contributor.institutionUniv Port Harcourt
dc.contributor.institutionGeorge Mason Univ
dc.contributor.institutionHeidelberg Univ
dc.contributor.institutionAll India Inst Med Sci
dc.contributor.institutionHebrew Univ Jerusalem
dc.contributor.institutionCase Western Reserve Univ
dc.contributor.institutionMakerere Univ
dc.contributor.institutionUniv S Africa
dc.contributor.institutionKwame Nkrumah Univ Sci & Technol
dc.contributor.institutionUniv Tasmania
dc.contributor.institutionNova SE Univ
dc.contributor.institutionMinist Hlth
dc.contributor.institutionUniv Miami
dc.contributor.institutionSwansea Univ
dc.contributor.institutionMulago Hosp
dc.contributor.institutionAsian Pacific Soc Cardiol
dc.contributor.institutionUniv Cape Town
dc.contributor.institutionLegacy Hlth Syst
dc.contributor.institutionNorthwestern Univ
dc.contributor.institutionNatl Inst Psychiat Ramon de la Fuente
dc.contributor.institutionThomas Jefferson Univ
dc.contributor.institutionPacific Inst Res & Evaluat
dc.contributor.institutionNatl Inst Hlth
dc.contributor.institutionUniv Eduardo Mondlane
dc.contributor.institutionDuke Univ
dc.contributor.institutionIRCCS Burlo Garofolo
dc.contributor.institutionColumbia Univ
dc.contributor.institutionQueensland Univ Technol
dc.contributor.institutionNatl Ctr Child Hlth & Dev
dc.contributor.institutionWatford Dist Gen Hosp
dc.contributor.institutionKemri Wellcome Trust
dc.contributor.institutionUniv KwaZulu Natal
dc.contributor.institutionCtr Studi GISED
dc.contributor.institutionCharite
dc.contributor.institutionNatl Univ Ireland Galway
dc.contributor.institutionDeakin Univ
dc.contributor.institutionBP Koirala Inst Hlth Sci
dc.contributor.institutionBetty Cowan Res & Innovat Ctr
dc.contributor.institutionHosp Joan 23
dc.contributor.institutionUniv Calgary
dc.contributor.institutionInst Nacl Enfermedades Resp
dc.contributor.institutionHosp Univ Cruces
dc.contributor.institutionShanghai Jiao Tong Univ
dc.contributor.institutionBrigham Young Univ
dc.contributor.institutionCtr Addict & Mental Hlth
dc.contributor.institutionHosp Univ Canarias
dc.contributor.institutionUniv British Columbia
dc.contributor.institutionVector Control Res Ctr
dc.contributor.institutionCtr Dis Anal
dc.contributor.institutionUniv Calif Berkeley
dc.contributor.institutionUniv Chicago
dc.contributor.institutionComplejo Hosp Caja Seguro Social
dc.contributor.institutionTurning Point Alcohol & Drug Ctr
dc.contributor.institutionVanderbilt Univ
dc.contributor.institutionUniv Alabama Birmingham
dc.contributor.institutionMinist Interior
dc.contributor.institutionHlth Canada
dc.contributor.institutionQueens Med Ctr
dc.contributor.institutionNorwegian Univ Sci & Technol
dc.contributor.institutionAga Khan Univ
dc.contributor.institutionDrexel Univ
dc.contributor.institutionUniv Alberta
dc.contributor.institutionCincinnati Childrens Hosp
dc.contributor.institutionCopenhagen Univ Hosp
dc.contributor.institutionUniv Crete
dc.contributor.institutionANLIS
dc.contributor.institutionKNCV TB Fdn
dc.contributor.institutionMaastricht Univ
dc.contributor.institutionNatl Univ Singapore
dc.contributor.institutionCapital Med Univ
dc.contributor.institutionBrown Univ
dc.contributor.institutionRoyal Childrens Hosp
dc.contributor.institutionMurdoch Childrens Res Inst
dc.contributor.institutionUniv Nottingham
dc.contributor.institutionHollywood Orthopaed Grp
dc.contributor.institutionArthrit Res
dc.contributor.institutionRoyal Cornwall Hosp
dc.contributor.institutionLondon Sch Econ
dc.contributor.institutionLandstuhl Reg Med Ctr
dc.description.affiliationUniv Queensland, Queensland Ctr Mental Hlth Res, Brisbane, Qld, Australia
dc.description.affiliationUniv Queensland, Sch Populat Hlth, Brisbane, Qld, Australia
dc.description.affiliationUniv Queensland, Clin Res Ctr, Brisbane, Qld, Australia
dc.description.affiliationUniv Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
dc.description.affiliationUniv Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA
dc.description.affiliationUniv Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98121 USA
dc.description.affiliationUniv Washington, Dept Anesthesiol & Pain Med, Seattle, WA 98121 USA
dc.description.affiliationChina Med Board, Boston, MA USA
dc.description.affiliationUniv London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Dept Epidemiol & Biostat, MRC HPA Ctr Environm & Hlth, London, England
dc.description.affiliationUniv Tokyo, Dept Global Hlth Policy, Tokyo, Japan
dc.description.affiliationHarvard Univ, Dept Biostat, Boston, MA 02115 USA
dc.description.affiliationHarvard Univ, Sch Publ Hlth, Boston, MA 02115 USA
dc.description.affiliationHarvard Univ, Dept Epidemiol, Boston, MA 02115 USA
dc.description.affiliationHarvard Univ, Harvard Humanitarian Initiat, Boston, MA 02115 USA
dc.description.affiliationHarvard Univ, Boston Childrens Hosp, Boston, MA 02115 USA
dc.description.affiliationHarvard Univ, Brigham & Womens Hosp, Boston, MA 02115 USA
dc.description.affiliationHarvard Univ, Harvard Med Sch, Boston, MA 02115 USA
dc.description.affiliationDupuytren Univ Hosp, Dept Cardiol, Limoges, France
dc.description.affiliationUniv Texas San Antonio, San Antonio, TX USA
dc.description.affiliationUniv Melbourne, Ctr Int Child Hlth, Melbourne, Vic, Australia
dc.description.affiliationUniv Melbourne, Dept Pediat, Melbourne, Vic, Australia
dc.description.affiliationUniv Melbourne, Ctr Hlth Policy Programs & Econ, Melbourne, Vic, Australia
dc.description.affiliationUniv Melbourne, Sch Populat Hlth, Melbourne, Vic, Australia
dc.description.affiliationSanjay Gandhi Postgrad Inst Med Sci, Lucknow, Uttar Pradesh, India
dc.description.affiliationEmory Univ, Sch Publ Hlth, Atlanta, GA USA
dc.description.affiliationEmory Univ, Sch Med, Atlanta, GA USA
dc.description.affiliationSt Georges Univ London, London, England
dc.description.affiliationMayo Clin, Rochester, MN USA
dc.description.affiliationUniv Auckland, Auckland 1, New Zealand
dc.description.affiliationPontificia Univ Javeriana, Sch Engn, Dept Ind Engn, Bogota, Colombia
dc.description.affiliationYale Univ, New Haven, CT USA
dc.description.affiliationBoston Univ, Sch Med, Boston, MA 02118 USA
dc.description.affiliationUniv Oxford, Clin Trial Serv Unit, Oxford, England
dc.description.affiliationUniv Oxford, Epidemiol Studies Unit, Oxford, England
dc.description.affiliationKings Coll London, Inst Dent, London WC2R 2LS, England
dc.description.affiliationKings Coll London, Hosp NHS Trust, London WC2R 2LS, England
dc.description.affiliationKings Coll London, Inst Psychiat, London WC2R 2LS, England
dc.description.affiliationQueen Mary Univ London, Inst Dent, London, England
dc.description.affiliationMoscow State Univ Med & Dent, Res Inst Transplantol & Artificial Organs, Moscow, Russia
dc.description.affiliationKing Fahad Med City, Riyadh, Saudi Arabia
dc.description.affiliationMichigan State Univ, E Lansing, MI 48824 USA
dc.description.affiliationMRC, Epidemiol Unit, Cambridge, England
dc.description.affiliationLondon Sch Hyg & Trop Med, London WC1, England
dc.description.affiliationUniv Sydney, No Clin Sch, Dept Rheumatol, Sydney, NSW 2006, Australia
dc.description.affiliationUniv Sydney, Fac Hlth Sci, Sydney, NSW 2006, Australia
dc.description.affiliationUniv Sydney, Inst Bone & Joint Res, Sydney, NSW 2006, Australia
dc.description.affiliationUniv Sydney, Sydney Sch Publ Hlth, Sydney, NSW 2006, Australia
dc.description.affiliationINSERM, Paris, France
dc.description.affiliationUniv New S Wales, Natl Drug & Alcohol Res Ctr, Sydney, NSW, Australia
dc.description.affiliationUniv New S Wales, Sydney, NSW, Australia
dc.description.affiliationAnglia Ruskin Univ, Vis & Eye Res Unit, Cambridge, England
dc.description.affiliationMoorfields Eye Hosp, London, England
dc.description.affiliationUniv Cambridge, Cambridge, England
dc.description.affiliationUniv Leicester, Leicester, Leics, England
dc.description.affiliationFlinders Univ S Australia, Adelaide, SA 5001, Australia
dc.description.affiliationCabrini Inst, Malvern, Vic, Australia
dc.description.affiliationMonash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic 3004, Australia
dc.description.affiliationJohns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA
dc.description.affiliationTexas A&M Univ, College Stn, TX USA
dc.description.affiliationGreat Ormond St Hosp Sick Children, London WC1N 3JH, England
dc.description.affiliationWashington Univ, St Louis, MO USA
dc.description.affiliationUniv Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA
dc.description.affiliationUniv Western Australia, Telethon Inst Child Hlth Res, Ctr Child Hlth Res, Perth, WA 6009, Australia
dc.description.affiliationUniv Camilo Jose Cela, Villanueva De La Canada, Spain
dc.description.affiliationMario Negri Inst Pharmacol Res, I-24100 Bergamo, Italy
dc.description.affiliationNIEHS, Res Triangle Pk, NC 27709 USA
dc.description.affiliationAcad Sinica, Inst Biomed Sci, Taipei, Taiwan
dc.description.affiliationCedars Sinai Med Ctr, Inst Heart, Los Angeles, CA 90048 USA
dc.description.affiliationUniv Med Ctr Rotterdam, Erasmus MC, Dept Publ Hlth, Rotterdam, Netherlands
dc.description.affiliationMenzies Sch Hlth Res, Darwin, NT, Australia
dc.description.affiliationNatl Hlth Serv, Edinburgh, Midlothian, Scotland
dc.description.affiliationUniv Edinburgh, Edinburgh, Midlothian, Scotland
dc.description.affiliationUniv Witwatersrand, Johannesburg, South Africa
dc.description.affiliationLoyola Univ, Sch Med, Chicago, IL 60611 USA
dc.description.affiliationWake Forest Univ, Sch Publ Hlth Sci, Winston Salem, NC 27109 USA
dc.description.affiliationHosp Dr Gustavo N Collado, Puerto Chitre, Panama
dc.description.affiliationVictorian Infect Dis Reference Lab, Melbourne, Vic, Australia
dc.description.affiliationUniv Calif San Diego, San Diego, CA 92103 USA
dc.description.affiliationUniv Penn, Philadelphia, PA 19104 USA
dc.description.affiliationBldg & Rd Res Inst, Kumasi, Ghana
dc.description.affiliationMRC Hearing & Commun Grp, Manchester, Lancs, England
dc.description.affiliationGriffith Univ, Sch Dent & Oral Hlth, Brisbane, Qld 4111, Australia
dc.description.affiliationGriffith Univ, Populat & Social Hlth Res Program, Brisbane, Qld 4111, Australia
dc.description.affiliationDenver VA Med Ctr, Denver, VA USA
dc.description.affiliationUniv Otago, Dunedin, New Zealand
dc.description.affiliationBeth Israel Deaconess Med Ctr, New York, NY 10003 USA
dc.description.affiliationUniv Peradeniya, Peradeniya, Sri Lanka
dc.description.affiliationUniv Liverpool, Liverpool L69 3BX, Merseyside, England
dc.description.affiliationHosp Santa Creu & Sant Pau, Barcelona, Spain
dc.description.affiliationUniv Ulster, Ulster, Ireland
dc.description.affiliationFed Minist Hlth, Khartoum, Sudan
dc.description.affiliationHosp Maciel, Montevideo, Uruguay
dc.description.affiliationEmerald Publ Hlth Consulting Serv Ltd, Abuja, Nigeria
dc.description.affiliationUniv Tehran Med Sci, Digest Dis Res Ctr, Tehran, Iran
dc.description.affiliationAuckland Tech Univ, Natl Inst Stroke & Appl Neurosci, Auckland, New Zealand
dc.description.affiliationUniv Fed Sao Paulo, Sch Med, Sao Paulo, Brazil
dc.description.affiliationCarnegie Mellon Univ, Pittsburgh, PA 15213 USA
dc.description.affiliationJames Cook Univ, Townsville, Qld 4811, Australia
dc.description.affiliationHoward Univ, Coll Med, Washington, DC USA
dc.description.affiliationAddict Info Switzerland, Lausanne, Switzerland
dc.description.affiliationUniv Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA
dc.description.affiliationSuny Downstate Med Ctr, Coll Med, Brooklyn, NY 11203 USA
dc.description.affiliationCtr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA USA
dc.description.affiliationUniv Lorraine, Nancy, France
dc.description.affiliationUniv Bristol, Bristol, Avon, England
dc.description.affiliationNYU, New York, NY USA
dc.description.affiliationBrandeis Univ, Waltham, MA USA
dc.description.affiliationUniv Barcelona, CIBERSAM, St Boi De Llobregat, Spain
dc.description.affiliationKarolinska Univ Hosp, Stockholm, Sweden
dc.description.affiliationQueen Elizabeth Hosp, Adelaide, SA, Australia
dc.description.affiliationUniv Franche Comte, F-25030 Besancon, France
dc.description.affiliationCtr Hosp Reg Univ Besancon, Besancon, France
dc.description.affiliationNIDCD, NIH, Bethesda, MD USA
dc.description.affiliationNIDDK, NIH, Bethesda, MD USA
dc.description.affiliationBaylor Coll Med, Natl Sch Trop Med, Waco, TX USA
dc.description.affiliationUniv Port Harcourt, Port Harcourt, Nigeria
dc.description.affiliationGeorge Mason Univ, Fairfax, VA 22030 USA
dc.description.affiliationHeidelberg Univ, Med Fac Mannheim, Dept Ophthalmol, Heidelberg, Germany
dc.description.affiliationAll India Inst Med Sci, New Delhi, India
dc.description.affiliationHebrew Univ Jerusalem, Hadassah Med Sch, Dept Cardiol, IL-91010 Jerusalem, Israel
dc.description.affiliationCase Western Reserve Univ, Cleveland, OH 44106 USA
dc.description.affiliationMakerere Univ, Sch Publ Hlth, Kampala, Uganda
dc.description.affiliationUniv S Africa, Johannesburg, South Africa
dc.description.affiliationKwame Nkrumah Univ Sci & Technol, Kumasi, Ghana
dc.description.affiliationUniv Tasmania, Hobart, Tas 7001, Australia
dc.description.affiliationNova SE Univ, Ft Lauderdale, FL 33314 USA
dc.description.affiliationMinist Hlth, Jerusalem, Israel
dc.description.affiliationUniv Miami, Miller Sch Med, Miami, FL 33136 USA
dc.description.affiliationSwansea Univ, Swansea, W Glam, Wales
dc.description.affiliationMulago Hosp, Kampala, Uganda
dc.description.affiliationAsian Pacific Soc Cardiol, Kyoto, Japan
dc.description.affiliationMRC, Tygerberg, South Africa
dc.description.affiliationUniv Cape Town, Hatter Inst, ZA-7925 Cape Town, South Africa
dc.description.affiliationUniv Cape Town, Dept Med, ZA-7925 Cape Town, South Africa
dc.description.affiliationLegacy Hlth Syst, Portland, OR USA
dc.description.affiliationNorthwestern Univ, Feinberg Sch Med, Evanston, IL USA
dc.description.affiliationNatl Inst Psychiat Ramon de la Fuente, Mexico City, DF, Mexico
dc.description.affiliationThomas Jefferson Univ, Philadelphia, PA 19107 USA
dc.description.affiliationPacific Inst Res & Evaluat, Calverton, MD USA
dc.description.affiliationNatl Inst Hlth, Maputo, Mozambique
dc.description.affiliationUniv Eduardo Mondlane, Maputo, Mozambique
dc.description.affiliationDuke Univ, Durham, NC USA
dc.description.affiliationIRCCS Burlo Garofolo, Inst Maternal & Child Hlth, Trieste, Italy
dc.description.affiliationColumbia Univ, Mailman Sch Publ Hlth, New York, NY USA
dc.description.affiliationQueensland Univ Technol, Brisbane, Qld 4001, Australia
dc.description.affiliationNatl Ctr Child Hlth & Dev, Tokyo, Japan
dc.description.affiliationWatford Dist Gen Hosp, Watford, England
dc.description.affiliationKemri Wellcome Trust, Kilifi, Kenya
dc.description.affiliationUniv KwaZulu Natal, AVRI, Durban, South Africa
dc.description.affiliationCtr Studi GISED, Bergamo, Italy
dc.description.affiliationCharite, D-13353 Berlin, Germany
dc.description.affiliationNatl Univ Ireland Galway, HRB Clin Res Facil, Galway, Ireland
dc.description.affiliationDeakin Univ, Melbourne, Vic, Australia
dc.description.affiliationBP Koirala Inst Hlth Sci, Dharan, Nepal
dc.description.affiliationBetty Cowan Res & Innovat Ctr, Ludhiana, Punjab, India
dc.description.affiliationHosp Joan 23, La Paz, Bolivia
dc.description.affiliationUniv Calgary, Calgary, AB, Canada
dc.description.affiliationInst Nacl Enfermedades Resp, Mexico City, DF, Mexico
dc.description.affiliationHosp Univ Cruces, Baracaldo, Spain
dc.description.affiliationShanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Sch Med, Shanghai 200030, Peoples R China
dc.description.affiliationShanghai Jiao Tong Univ, Sch Publ Hlth, Shanghai 200030, Peoples R China
dc.description.affiliationBrigham Young Univ, Provo, UT 84602 USA
dc.description.affiliationCtr Addict & Mental Hlth, Toronto, ON, Canada
dc.description.affiliationHosp Univ Canarias, Tenerif, Spain
dc.description.affiliationUniv British Columbia, Fac Med, Sch Populat & Publ Hlth, Vancouver, BC, Canada
dc.description.affiliationVector Control Res Ctr, Pondicherry, India
dc.description.affiliationCtr Dis Anal, Louisville, CO USA
dc.description.affiliationUniv Calif Berkeley, Berkeley, CA 94720 USA
dc.description.affiliationUniv Chicago, NORC, Chicago, IL 60637 USA
dc.description.affiliationComplejo Hosp Caja Seguro Social, Panama City, Panama
dc.description.affiliationTurning Point Alcohol & Drug Ctr, Ctr Alcohol Policy Res, Fitzroy, SA, Australia
dc.description.affiliationVanderbilt Univ, Nashville, TN USA
dc.description.affiliationUniv Alabama Birmingham, Birmingham, AL USA
dc.description.affiliationMinist Interior, Madrid, Spain
dc.description.affiliationHlth Canada, Ottawa, ON K1A 0L2, Canada
dc.description.affiliationQueens Med Ctr, Honolulu, HI USA
dc.description.affiliationNorwegian Univ Sci & Technol, Dept Neurosci, N-7034 Trondheim, Norway
dc.description.affiliationAga Khan Univ, Karachi, Pakistan
dc.description.affiliationDrexel Univ, Sch Publ Hlth, Philadelphia, PA 19104 USA
dc.description.affiliationUniv Alberta, Alberta Kidney Dis Network, Edmonton, AB, Canada
dc.description.affiliationCincinnati Childrens Hosp, Cincinnati, OH USA
dc.description.affiliationCopenhagen Univ Hosp, Dept Neurol, Herlev, Denmark
dc.description.affiliationUniv Crete, Sch Med, Iraklion, Greece
dc.description.affiliationANLIS, Inst Nacl Epidemiol, Malbran, Argentina
dc.description.affiliationKNCV TB Fdn, The Hague, Netherlands
dc.description.affiliationMaastricht Univ, Med Ctr, Maastricht, Netherlands
dc.description.affiliationNatl Univ Singapore, Singapore 117548, Singapore
dc.description.affiliationCapital Med Univ, Beijing Neurosurg Inst, Beijing, Peoples R China
dc.description.affiliationBrown Univ, Providence, RI 02912 USA
dc.description.affiliationRoyal Childrens Hosp, Melbourne, Vic, Australia
dc.description.affiliationMurdoch Childrens Res Inst, Melbourne, Vic, Australia
dc.description.affiliationUniv Nottingham, Nottingham NG7 2RD, England
dc.description.affiliationHollywood Orthopaed Grp, Perth, WA, Australia
dc.description.affiliationArthrit Res, Wichita, KS USA
dc.description.affiliationRoyal Cornwall Hosp, Truro, England
dc.description.affiliationLondon Sch Econ, London WC2A 2AE, England
dc.description.affiliationLandstuhl Reg Med Ctr, Landstuhl, Germany
dc.description.affiliationUnifespUniv Fed Sao Paulo, Sch Med, Sao Paulo, Brazil
dc.description.sponsorshipIDWellcome Trust: 098045
dc.description.sponsorshipIDWellcome Trust: 085308
dc.description.sponsorshipIDNIH: K23 AG034236
dc.description.sponsorshipIDSwedish Research Council: 2011-1071
dc.description.sponsorshipIDJapan Ministry of Health, Labour, and Welfare: H13-SHOGAI-023
dc.description.sponsorshipIDJapan Ministry of Health, Labour, and Welfare: H14-TOKUBETSU-026
dc.description.sponsorshipIDJapan Ministry of Health, Labour, and Welfare: H16-KOKORO-013
dc.description.sponsorshipIDBiostatistics, Epidemiologic and Bioinformatic Training in Environmental Health Training Grant: ES015459
dc.description.sponsorshipIDNational Institute of Environmental Health Sciences: ES00260
dc.identifier.doi10.1016/S0140-6736(12)61689-4
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000312387000016


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