Early life adversity, genomic plasticity, and psychopathology

Early life adversity, genomic plasticity, and psychopathology

Author Turecki, Gustavo Google Scholar
Ota, Vanessa Kiyomi Autor UNIFESP Google Scholar
Belangero, Sintia Iole Autor UNIFESP Google Scholar
Jackowski, Andrea Autor UNIFESP Google Scholar
Kaufman, Joan Google Scholar
Institution McGill Univ
Universidade Federal de São Paulo (UNIFESP)
Yale Univ
Abstract Child maltreatment is associated with an increased risk of psychiatric disorders, and a range of health problems later in life. Research suggests that adverse events early in life can lead to changes in gene expression through epigenetic mechanisms that alter stress reactivity, brain function, and behaviour. Although epigenetic changes are often long lasting, they can be reversed with pharmacological and environmental manipulations. The complexity of the epigenome is not fully understood. The aim of this Review is to assess emerging data for the role of epigenetic mechanisms in stress-related psychiatric disorders with a focus on future research. We describe the epigenetic processes, key findings in this specialty, clinical implications of research, and methodological issues. Studies are needed to investigate new epigenetic processes other than methylation and assess the efficacy of interventions to reverse epigenetic processes associated with the effects of early life adversity.
Language English
Sponsor Canadian Institute of Health Research
National Institutes of Health
Fonds de Recherche du Quebec-Sante through a Chercheur National salary award
Fonds de Recherche du Quebec-Sante through the Quebec Network on Suicide, Mood Disorders and Related Disorders
Grant number Canadian Institute of Health Research: MOP93775
Canadian Institute of Health Research: MOP11260
Canadian Institute of Health Research: MOP119429
Canadian Institute of Health Research: MOP119430
National Institutes of Health: 1R01DA033684-01
Date 2014-11-01
Published in Lancet Psychiatry. Oxford: Elsevier Sci Ltd, v. 1, n. 6, p. 461-466, 2014.
ISSN 2215-0374 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 461-466
Origin http://dx.doi.org/10.1016/S2215-0366(14)00022-4
Access rights Closed access
Type Review
Web of Science ID WOS:000345635400027
URI http://repositorio.unifesp.br/11600/44818

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