Female gout: Clinical and laboratory features

Female gout: Clinical and laboratory features

Author De Souza, Alexandre WS Google Scholar
Fernandes, Vander Google Scholar
Ferrari, Antonio JL Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Objective. To evaluate and compare clinical and laboratory features of gout in men and women.Methods. Twenty-seven women and 31 men with gout underwent clinical and laboratory evaluation and review of medical records.Results. Disease onset in women was a mean of 7 years later than in men. There were no differences between women and men regarding systemic hypertension, diabetes mellitus, hyperlipidemia, chronic renal failure, renal stones, ischemic heart disease, or heavy alcohol consumption. Tophaceous gout was similar in both groups, although female gender seemed to be protective against risk of developing tophi (odds ratio: 0.449; 95% confidence interval: 0.151-1.330). Podagra was more common in men, and women showed a higher frequency of upper limb joint involvement. Most patients had low urate excretion rates. Achieving disease control was similar in women and men. Of the 8 women who were premenopausal at disease onset, 7 had secondary causes for gout; 5 of the 8 had high serum urate despite treatment.Conclusion. Gout in women had a later onset and higher frequency of upper limb joint involvement in comparison to men. Those with premenopausal onset tended to be refractory to standard therapy.
Keywords gout
uric acid
Language English
Date 2005-11-01
Published in Journal Of Rheumatology. Toronto: J Rheumatol Publ Co, v. 32, n. 11, p. 2186-2188, 2005.
ISSN 0315-162X (Sherpa/Romeo, impact factor)
Publisher J Rheumatol Publ Co
Extent 2186-2188
Origin http://www.jrheum.org/content/32/11/2186
Access rights Closed access
Type Article
Web of Science ID WOS:000233139400024
URI http://repositorio.unifesp.br/11600/44677

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