Immunohistochemical analysis of adhesion molecule expression on muscle biopsy specimens from patients with juvenile dermatomyositis

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dc.contributor.author Sallum, Adriana ME
dc.contributor.author Marie, Suely KN
dc.contributor.author Wakamatsu, Alda
dc.contributor.author Sachetti, Silvana
dc.contributor.author Vianna, Maria AG
dc.contributor.author Silva, Clóvis AA
dc.contributor.author Kiss, Maria HB
dc.date.accessioned 2018-06-18T10:46:10Z
dc.date.available 2018-06-18T10:46:10Z
dc.date.issued 2004-04-01
dc.identifier http://www.jrheum.org/content/31/4/801
dc.identifier.citation Journal Of Rheumatology. Toronto: J Rheumatol Publ Co, v. 31, n. 4, p. 801-807, 2004.
dc.identifier.issn 0315-162X
dc.identifier.uri http://repositorio.unifesp.br/11600/44674
dc.description.abstract Objective. To assess expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) on muscle biopsy specimens from patients with untreated juvenile dermatomyositis (JDM).Methods. Histochemical and immunohistochemical tests for ICAM-1 and VCAM-1 were performed on serial frozen sections from 27 JDM muscle biopsy specimens. ICAM-1 and VCAM-1 expression was analyzed on capillaries, perimysial and endomysial large vessels, and muscle fibers. Expression was assessed and graded semiquantitatively.Results. Increased ICAM-1 expression was observed on capillaries and perimysial large vessels on semiquantitative analysis, and was statistically more evident than on endomysial large vessels. In all cases, only a few muscle vessels showed expression of VCAM-1. Expression of ICAM-1 and VCAM-1 was observed on few muscle fibers.Conclusion. The observation of ICAM-1 expression on muscle vessels, mainly on capillaries of patients with untreated JDM compared to controls, and. VCAM-1 expression to a lesser extent, mostly on muscle vessels surrounded by inflammatory infiltrate, supports the participation of these adhesion molecules in the pathologic mechanism of vascular injury in JDM. en
dc.format.extent 801-807
dc.language.iso eng
dc.publisher J Rheumatol Publ Co
dc.relation.ispartof Journal Of Rheumatology
dc.rights Acesso restrito
dc.subject juvenile dermatomyositis en
dc.subject adhesion molecules en
dc.subject muscle biopsy en
dc.subject intercellular adhesion molecule-1 en
dc.subject vascular cell adhesion molecule-1 en
dc.title Immunohistochemical analysis of adhesion molecule expression on muscle biopsy specimens from patients with juvenile dermatomyositis en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution Adolfo Lutz Inst
dc.description.affiliation Univ Sao Paulo, Sch Med, Dept Pediat, Sao Paulo, Brazil
dc.description.affiliation Univ Sao Paulo, Sch Med, Dept Neurol, Sao Paulo, Brazil
dc.description.affiliation Univ Sao Paulo, Sch Med, Dept Rheumatol, Sao Paulo, Brazil
dc.description.affiliation Sanat Casa Misericordia Sao Paulo Med Sch, Dept Pediat, Sao Paulo, Brazil
dc.description.affiliation Adolfo Lutz Inst, Sao Paulo, Brazil
dc.description.source Web of Science
dc.identifier.wos WOS:000220673000031



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