Photorefractive keratectomy with mitomycin C versus LASIK in custom surgeries for myopia: A bilateral prospective randomized clinical trial

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Data
2008-04-01
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Wallau, Anelise Dutra [UNIFESP]
Campos, Mauro [UNIFESP]
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PURPOSE: To compare photorefractive keratectomy (PRK) with prophylactic use of mitomycin C (MMC) and LASIK in custom surgeries for myopic astigmatism.METHODS: Eighty-eight eyes of 44 patients with a minimum estimated ablation depth of 50 pm were randomized to receive PRK with MMC 0.002% for 1 minute in one eye and LASIK in the fellow eye. Uncorrected visual acuity (UCVA), best spectacle-corrected visual acuity (BSCVA), cycloplegic refraction, slit-lamp microscopy, contrast sensitivity, specular microscopy, aberrometry, and a subjective questionnaire were evaluated. Forty-two patients completed 6-month follow-up.RESULTS: Mean spherical equivalent refraction error before surgery and mean ablation depth were -3.99 +/- 1.20 diopters (D) and 73.09 +/- 14.55 mu m in LASIK eyes, and -3.85 +/- 1.12 D and 70.7 +/- 14.07 mu m in PRK with MMC eyes, respectively. Uncorrected visual acuity was significantly better in PRK with MMC eyes 3 months (P=.04) and 6 months (P=.01) after surgery. Best spectacle-corrected visual acuity and spherical equivalent refraction did not differ significantly in the groups during follow-up (P>.05). Significant haze was not observed in any PRK with MMC eye. Mean higher order aberration was lower in PRK with MMC eyes postoperatively compared with LASIK eyes (P=.01). Better contrast sensitivity was observed in PRK with MMC eyes than LASIK eyes (P<.05). The endothelial cell count did not differ significantly between groups (P=.65). In terms of visual satisfaction, PRK with MMC eyes were better rated.CONCLUSIONS: Photorefractive keratectomy with MMC appears to be more effective than LASIK in custom Surgery for moderate myopia. During 6-month follow-up, no toxic effects of MMC were evident. Long-term follow-up is necessary to attest its safety.
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Journal Of Refractive Surgery. Thorofare: Slack Inc, v. 24, n. 4, p. 326-336, 2008.
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