The addition of ifosfamide/etoposide to cisplatin/teniposide improves the survival of children with retinoblastoma and orbital involvement
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2007-10-01
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Antoneli, Celia Beatriz Gianotti
Ribeiro, Karina Braga
Rodriguez-Galindo, Carlos
Soares, Fernando Augusto
Arias, Victor Eduardo Arrúa
Novaes, Paulo Eduardo Ribeiro dos Santos
Chojniak, Martha Maria Motono [UNIFESP]
Malogolowkin, Márcio
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This study aimed to determine the impact of the addition of ifosfamide/etoposide to a regimen containing cisplatin/temposide on the survival of patients with retinoblastoma with orbital involvement. Thirty patients were treated at the A. C. Camargo Hospital, Brazil, from 1986 to 2002. From 1986 to April 1992 (period 1, n = 12), treatment consisted of 3 cycles of induction chemotherapy with cisplatin and teniposide, followed by maintenance with same drugs alternating with cyclophosphamide. vincristine, and doxorubicin every 21 days for 60 weeks. Since April 1992 (period 11, n = 18), the treatment consisted of 3 cycles of ifamide and etoposide followed by maintenance with same drugs, alternating with cisplatin and teniposide every 21 days for 36 weeks. In both periods, children were submitted to exenteration with eyelid preservation and orbital radiation therapy with 45cGy, and also received intrathecal therapy with methotrexate plus dexamethasone and cytarabine. Kaplan-Meier method was used for survival analysis. The median age was 31 months. Most patients (86.7%) presented unilateral tumors. The 3-year overall survival was 34.4% and 72.2%, respectively, for patients treated during periods I and 11 (P = 0.061). The addition of ifosfamide/etoposide to chemotherapy with cisplatin/teniposide improves survival in these patients, but further studies are still necessary.
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Journal Of Pediatric Hematology Oncology. Philadelphia: Lippincott Williams & Wilkins, v. 29, n. 10, p. 700-704, 2007.