Adrenal steroids synthesis during acute infectious diseases in infants

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dc.contributor.author Longui, C. A.
dc.contributor.author Zlochevsky, ERM
dc.contributor.author Bachega, Tania Aparecida Sartori Sanchez [UNIFESP]
dc.contributor.author Monte, O.
dc.date.accessioned 2018-06-15T18:07:32Z
dc.date.available 2018-06-15T18:07:32Z
dc.date.issued 2002-11-01
dc.identifier http://dx.doi.org/10.1515/JPEM.2002.15.9.1515
dc.identifier.citation Journal Of Pediatric Endocrinology & Metabolism. London: Freund Publishing House Ltd, v. 15, n. 9, p. 1515-1523, 2002.
dc.identifier.issn 0334-018X
dc.identifier.uri http://repositorio.unifesp.br/11600/44537
dc.description.abstract An increase in plasma 17OHP found in infants requiring differential diagnosis between septic shock and adrenal failure led us to look for adrenal steroids pattern during infection. Infants and Methods: 56 infants, 1-6 months old, were studied during infection of different degrees of severity. Plasma cortisol, 17OHP, androstenedione, DHEA, DHEA-S and testosterone were measured.Results: 24 patients showed an expected cortisol elevation. One child had a low cortisol level. The concentration of 17OHP was above 6.0 nmol/l (200 ng/dl) in 41 patients and above 30.2 nmol/l (1,000 ng/dl) in 10. Higher 17OHP levels and more severe diseases correlated positively.Conclusions: During infectious diseases some patients demonstrated not only cortisol elevation but also 17OHP as high as that observed in NC-CAH. We suggest that if 17OHP elevation is not characteristic of SL-CAH, glucocorticoid therapy should be started and an ACTH test should be performed after recovery before ruling out this pathology. en
dc.format.extent 1515-1523
dc.language.iso eng
dc.publisher Freund Publishing House Ltd
dc.relation.ispartof Journal Of Pediatric Endocrinology & Metabolism
dc.rights Acesso restrito
dc.subject adrenal gland en
dc.subject adrenal steroids en
dc.subject cortisol en
dc.subject 17-hydroxyprogesterone en
dc.subject acute infectious diseases en
dc.subject critical care patients en
dc.title Adrenal steroids synthesis during acute infectious diseases in infants en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade de São Paulo (USP)
dc.description.affiliation Santa Casa Sao Paulo, Sch Med, Pediat Endocrinol Unit, Dept Pediat, Sao Paulo, Brazil
dc.description.affiliation Hosp Municipal Infantil Menino Jesus, Pediat Intens Care Unit, Sao Paulo, Brazil
dc.description.affiliation Univ Sao Paulo, Sch Med, Dept Endocrinol, Endocrinol Unit Dev & Hormones, Sao Paulo, Brazil
dc.description.affiliation Univ Sao Paulo, Sch Med, Dept Endocrinol, Mol Genet Lab, Sao Paulo, Brazil
dc.identifier.doi 10.1515/JPEM.2002.15.9.1515
dc.description.source Web of Science
dc.identifier.wos WOS:000179823400008



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