Adrenal steroids synthesis during acute infectious diseases in infants

Adrenal steroids synthesis during acute infectious diseases in infants

Author Longui, C. A. Google Scholar
Zlochevsky, ERM Google Scholar
Bachega, Tania Aparecida Sartori Sanchez Autor UNIFESP Google Scholar
Monte, O. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract An increase in plasma 17OHP found in infants requiring differential diagnosis between septic shock and adrenal failure led us to look for adrenal steroids pattern during infection. Infants and Methods: 56 infants, 1-6 months old, were studied during infection of different degrees of severity. Plasma cortisol, 17OHP, androstenedione, DHEA, DHEA-S and testosterone were measured.Results: 24 patients showed an expected cortisol elevation. One child had a low cortisol level. The concentration of 17OHP was above 6.0 nmol/l (200 ng/dl) in 41 patients and above 30.2 nmol/l (1,000 ng/dl) in 10. Higher 17OHP levels and more severe diseases correlated positively.Conclusions: During infectious diseases some patients demonstrated not only cortisol elevation but also 17OHP as high as that observed in NC-CAH. We suggest that if 17OHP elevation is not characteristic of SL-CAH, glucocorticoid therapy should be started and an ACTH test should be performed after recovery before ruling out this pathology.
Keywords adrenal gland
adrenal steroids
cortisol
17-hydroxyprogesterone
acute infectious diseases
critical care patients
Language English
Date 2002-11-01
Published in Journal Of Pediatric Endocrinology & Metabolism. London: Freund Publishing House Ltd, v. 15, n. 9, p. 1515-1523, 2002.
ISSN 0334-018X (Sherpa/Romeo, impact factor)
Publisher Freund Publishing House Ltd
Extent 1515-1523
Origin http://dx.doi.org/10.1515/JPEM.2002.15.9.1515
Access rights Closed access
Type Article
Web of Science ID WOS:000179823400008
URI http://repositorio.unifesp.br/11600/44537

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