Impairment in Anthropometric Parameters and Body Composition in Females with Classical 21-Hydroxylase Deficiency

Date
2009-06-01Author
Goncalves, Ezequiel Moreira
Valente de Lemos-Marini, Sofia Helena
Mello, Maricilda Palandi de
Matias Baptista, Maria Tereza
Rodrigues D'Souza-Li, Lilia Freire
Baldin, Alexandre Duarte
Gomes Carvalho, Wellington Roberto
Farias, Edson Santos
Guerra-Junior, Gil
Type
ArtigoISSN
0334-018XIs part of
Journal Of Pediatric Endocrinology & MetabolismDOI
10.1515/JPEM.2009.22.6.519Metadata
Show full item recordAbstract
The aim of this study was to evaluate the physical measurements and body composition of female patients with the classic form of congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency. Twenty-eight girls with CAH were classified according to both hormonal control (well or not well controlled) and the clinical form of the disease (simple virilizing or salt-wasting). In the control group, 112 healthy individuals were included, divided into two subgroups (male and female). Both patients and controls were subdivided by age into three groups according to pubertal stage: <= 10 years (prepubertal), 11-15 years (pubertal), and >= 15 years (postpubertal). Anthropometrical evaluations and bioelectrical impedance were used to obtain the physical measurement and body composition data. The patients with the simple virilizing form presented higher values for BMI, waist, arm fat area, and fat mass percentage. The not well controlled group presented shorter leg length. Values obtained for BMI as well as for arm fat area, brachial circumference, waist, hip, bi-iliac diameter and fat mass percentage were significantly higher in the patients than in the controls, whereas leg length, hand size and the percentages of water and lean mass were lower. Alterations in body composition were observed in all age groups, mainly by increase of fat mass with age. After puberty, impairments in limb measurements (leg, hand and foot) were more evident. Patients with CAH presented differences in anthropometric parameters but mainly in body composition. Hence, more comprehensive and careful anthropometric evaluation during monitoring of patients with CAH is recommended.
Citation
Journal Of Pediatric Endocrinology & Metabolism. Berlin: Walter De Gruyter Gmbh, v. 22, n. 6, p. 519-529, 2009.Sponsorship
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Collections
- EPM - Artigos [17701]