Treatment of Resistant Obsessive-Compulsive Disorder With Ventral Capsular/Ventral Striatal Gamma Capsulotomy: A Pilot Prospective Study

Date
2009-09-01Author
Lopes, Antonio Carlos
Greenberg, Benjamin D.
Noren, Georg
Canteras, Miguel Montes
Busatto, Geraldo F.
Mathis, Maria Eugenia de
Taub, Anita
D'Alcante, Carina Chaubet
Hoexter, Marcelo Queiroz [UNIFESP]
Gouvea, Fernando Sauerbronn
Cecconi, Janaina Philippi
Gentil, Andre F.
Ferrao, Ygor Arzeno
Fuentes, Daniel
Castro, Claudio Campi de
Leite, Claudia C.
Salvajoli, Joao Victor
Duran, Fabio L. S.
Rasmussen, Steven
Miguel, Euripedes Constantino
Type
ArtigoISSN
0895-0172Is part of
Journal Of Neuropsychiatry And Clinical NeurosciencesDOI
10.1176/jnp.2009.21.4.381Metadata
Show full item recordAbstract
A subgroup of obsessive-compulsive disorder (OCD) patients remains refractory to conventional treatments. For them, a new stereotactic radiosurgery has been recently developed: the ventral capsular/ventral striatal (VC/VS) gamma capsulotomy. The authors aim to report efficacy and adverse events of VC/VS gamma capsulotomy. Five refractory OCD patients were selected. The authors assessed OCD, anxiety and depressive symptoms, and side effects pre- and postoperatively. Three patients (60%) met response criteria 48 months after surgery. Adverse effects were episodic and transient. Ventral capsular/ventral striatal gamma capsulotomy holds therapeutic promise, with few adverse effects. (The Journal of Neuropsychiatry and Clinical Neurosciences 2009; 21:381-392)
Citation
Journal Of Neuropsychiatry And Clinical Neurosciences. Arlington: Amer Psychiatric Publishing, Inc, v. 21, n. 4, p. 381-392, 2009.Sponsorship
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Brazilian Council for Scientific and Technological Development
Collections
- EPM - Artigos [17701]