Treatment of Resistant Obsessive-Compulsive Disorder With Ventral Capsular/Ventral Striatal Gamma Capsulotomy: A Pilot Prospective Study

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Data
2009-09-01
Autores
Lopes, Antonio Carlos
Greenberg, Benjamin D.
Noren, Georg
Canteras, Miguel Montes
Busatto, Geraldo F.
Mathis, Maria Eugenia de
Taub, Anita
D'Alcante, Carina Chaubet
Hoexter, Marcelo Queiroz [UNIFESP]
Gouvea, Fernando Sauerbronn
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A subgroup of obsessive-compulsive disorder (OCD) patients remains refractory to conventional treatments. For them, a new stereotactic radiosurgery has been recently developed: the ventral capsular/ventral striatal (VC/VS) gamma capsulotomy. The authors aim to report efficacy and adverse events of VC/VS gamma capsulotomy. Five refractory OCD patients were selected. The authors assessed OCD, anxiety and depressive symptoms, and side effects pre- and postoperatively. Three patients (60%) met response criteria 48 months after surgery. Adverse effects were episodic and transient. Ventral capsular/ventral striatal gamma capsulotomy holds therapeutic promise, with few adverse effects. (The Journal of Neuropsychiatry and Clinical Neurosciences 2009; 21:381-392)
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Journal Of Neuropsychiatry And Clinical Neurosciences. Arlington: Amer Psychiatric Publishing, Inc, v. 21, n. 4, p. 381-392, 2009.
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