APOA4 Polymorphism as a Risk Factor for Unfavorable Lipid Serum Profile and Depression: A Cross-Sectional Study

APOA4 Polymorphism as a Risk Factor for Unfavorable Lipid Serum Profile and Depression: A Cross-Sectional Study

Author Ota, Vanessa Kiyomi Autor UNIFESP Google Scholar
Chen, Elizabeth Suchi Autor UNIFESP Google Scholar
Ejchel, Tatiana Flank Autor UNIFESP Google Scholar
Furuya, Tatiane Katsue Autor UNIFESP Google Scholar
Mazzotti, Diego Robles Autor UNIFESP Google Scholar
Cendoroglo, Maysa Seabra Autor UNIFESP Google Scholar
Ramos, Luiz Roberto Autor UNIFESP Google Scholar
Araujo, Lara Quirino Autor UNIFESP Google Scholar
Burbano, Rommel Rodriguez Autor UNIFESP Google Scholar
Cardoso Smith, Marilia de Arruda Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Introduction: APOA1/C3/A4/A5 gene cluster is closely involved in lipid metabolism, and its polymorphisms have been associated with coronary heart disease and lipid plasma levels. Here, we aimed to investigate associations of APOC3 (3238C9G, j482C9T, 1100C9T) and APOA4 (Gln360His, Thr347Ser) polymorphisms in 382 individuals from a cohort of a Longitudinal Brazilian Elderly Study with major agerelated morbidities and with lipid and protein serum levels.Materials and Methods: The whole sample was genotyped by polymerase chain reactionYrestriction fragment length polymorphism. Descriptive statistics, logistic regression analysis, Student t test, deviation from Hardy-Weinberg, Bonferroni correction for multiple testing, and haplotype analyses were performed.Results: Although APOC3 1100T allele carriers presented lower triglyceride and very low density lipoprotein levels than non-T carriers, these associations disappeared after Bonferroni correction (P > 0.05). Moreover, APOA4 360His allele was associated with depression (P = 0.03), increased triglyceride (P = 0.035) and very low density lipoprotein (P = 0.035) levels, and reduced HDL levels (P = 0.0005). Haplotype analyses found an association between His/C/C haplotype (Gln360His/-482C>T/1100C>T) with depression, but this result was due to Gln360His polymorphism.Conclusions: Our data suggest that 360His allele might be a risk factor for depression and unfavorable lipid profile and depression for elderly people in the Brazilian population.
Keywords APOC-III
elderly population
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenadoria de Aperfeicoamento de Pessoal de Ensino Superior (Brazil)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Date 2011-08-01
Published in Journal Of Investigative Medicine. Philadelphia: Lippincott Williams & Wilkins, v. 59, n. 6, p. 966-970, 2011.
ISSN 1081-5589 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 966-970
Origin http://dx.doi.org/10.2310/JIM.0b013e31822467cd
Access rights Closed access
Type Article
Web of Science ID WOS:000293062800030
URI http://repositorio.unifesp.br/11600/44469

Show full item record


File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)




My Account