Cutaneous immediate and late phase reactions to schistosomin in schistosomiasis patients

Cutaneous immediate and late phase reactions to schistosomin in schistosomiasis patients

Author Marotto, PCF Google Scholar
Michalany, N. S. Google Scholar
Vilela, M. P. Google Scholar
Mendes, N. F. Google Scholar
Mendes, E. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Cutaneous immediate and late phase reactions (LPR) to schistosomin were studied in 29 patients with schistosomiasis mansoni. In 12 of these patients, the determination of total and specific serum IgE by immunoenzymatic method against schistosome antigen was carried out using serum samples obtained on the same day as the cutaneous tests. Skin biopsies were taken from 4 typical LPRs. Immediate reactions occurred in all except one and LPRs in 12 (41.3%). Patients with positive cutaneous reactions had high levels of specific serum IgE against schistosome antigen. Histopathological studies showed a moderate exudate consisting mainly of neutrophils (60%) and eosinophils (40%). LPRs in schistosomiasis have the same characteristics reported in the medical literature in relation to time of appearence, morphology and histopathology. The immunopathogenic role played by LPRs in the patients remains to be clarified.
Keywords LATE PHASE REACTION
SCHISTOSOMIASIS
SCHISTOSOMIN
IGE
Language English
Date 1995-09-01
Published in Journal Of Investigational Allergology & Clinical Immunology. Barcelona: J R Prous Sa, v. 5, n. 5, p. 269-271, 1995.
ISSN 1018-9068 (Sherpa/Romeo, impact factor)
Publisher J R Prous Sa
Extent 269-271
Access rights Closed access
Type Article
Web of Science ID WOS:A1995TC48800004
URI http://repositorio.unifesp.br/11600/44443

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