GH-releasing peptide (GHRP-6)-induced ACTH release in patients with Addison's disease: Effect of glucocorticoid withdrawal

Show simple item record

dc.contributor.author Martins, Manoel Ricardo Alves [UNIFESP]
dc.contributor.author Pinto, ACAR [UNIFESP]
dc.contributor.author Brunner, E. [UNIFESP]
dc.contributor.author Silva, MRD [UNIFESP]
dc.contributor.author Lengyel, AMJ [UNIFESP]
dc.date.accessioned 2018-06-15T17:58:43Z
dc.date.available 2018-06-15T17:58:43Z
dc.date.issued 2003-02-01
dc.identifier http://dx.doi.org/10.1007/BF03345143
dc.identifier.citation Journal Of Endocrinological Investigation. Milan: Editrice Kurtis S R L, v. 26, n. 2, p. 143-147, 2003.
dc.identifier.issn 0391-4097
dc.identifier.uri http://repositorio.unifesp.br/11600/44352
dc.description.abstract GH releasing peptide (GHRP-6) is a synthetic hexapeptide with potent GH releasing activity both in man and in animals. This peptide is also able to stimulate ACTH and cortisol (F) release. It has been suggested that the ACTH responsiveness to GHRP-6 is modulated by circulating glucocorticoid levels. To further clarify this hypothesis, we studied the effect of GHRP-6 (1 ug/kg, iv) on ACTH and F release in patients with Addison's disease (no.=6) during replacement therapy and after 72 h of glucocorticoid withdrawal. Seven controls were also submitted to a single GHRP-6 test. In control subjects, ACTH values (pmol/l; mean+/-SE) increased from 2.9+/-0.8 to 4.7+/-1.4 (peak). AUC (pmol.min/l) values were 170.3+/-48.8. F (nmol/l) values increased from 257.0+/-42.9 to 367.0+/-50.8. In patients with Addison's disease there was an increase in ACTH levels from 38.1+/-7.1 to 174.9+/-79.4 after GHRP-6 administration. AUC values were 5490.4+/-2269.1. After 72 h withdrawal of glucocorticoid, there was an increase in basal ACTH values (1191.2+/-97.3), and a trend toward an increase in ACTH levels after GHRP-6 (p=0.053). Patients with Addison's disease on therapy showed a significantly higher ACTH response to GHRP-6 when compared to controls. Our results show that in patients with Addison's disease on replacement there is an increased ACTH release after GHRP-6 administration, compared to controls. After 72 h glucocorticoid withdrawal, this enhanced responsiveness is not maintained. Our data suggest that circulating glucocorticoids modulate GHRP-6-induced ACTH release and that multiple mechanisms may be involved in this process. (C) 2003, Editrice Kurtis. en
dc.format.extent 143-147
dc.language.iso eng
dc.publisher Editrice Kurtis S R L
dc.relation.ispartof Journal Of Endocrinological Investigation
dc.rights Acesso restrito
dc.subject GHRP-6 en
dc.subject ACTH en
dc.subject glucocorticoid en
dc.subject Addison's disease en
dc.subject cortisol en
dc.subject GHS en
dc.title GH-releasing peptide (GHRP-6)-induced ACTH release in patients with Addison's disease: Effect of glucocorticoid withdrawal en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ Fed Sao Paulo, Div Endocrinol, UNIFESP EPM, BR-04034970 Sao Paulo, SP, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Div Endocrinol, UNIFESP EPM, BR-04034970 Sao Paulo, SP, Brazil
dc.identifier.doi 10.1007/BF03345143
dc.description.source Web of Science
dc.identifier.wos WOS:000182140200010



File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search


Browse

Statistics

My Account