Promoter methylation analysis of SIRT3, SMARCA5, HTERT and CDH1 genes in aging and Alzheimer's disease

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2008-01-01
Autores
Silva, Patricia Natalia Oliveira da [UNIFESP]
Gigek, Carolina Oliveira [UNIFESP]
Leal, Mariana Ferreira [UNIFESP]
Bertolucci, Paulo Henrique Ferreira [UNIFESP]
Labio, Roger Willian de
Payão, Spencer Luiz Marques [UNIFESP]
Smith, Marilia de Arruda Cardoso [UNIFESP]
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Longevity related genes were investigated concerning promoter methylation. SIRT3, SMARCA5, HTERT and CDH1 promoters were analyzed in peripheral blood in relation to gender, age and Alzheimer's disease ( AD). Methylation Specifc PCR assay (MSP) was used. There were no significant differences in methylation frequencies of SIRT3, SMARCA5 and CDH1 among young, elderly and AD groups (p > 0.05), showing no association with aging or AD. On the other hand, HTERT methylation frequency was associated with the aging process, in that AD patients differed from elderly controls (p = 0.0086), probably due to telomere and immune dysfunctions involved in AD pathogenesis.
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Journal Of Alzheimers Disease. Amsterdam: Ios Press, v. 13, n. 2, p. 173-176, 2008.
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