Analgesic and antiinflammatory activities of the aqueous extract of Plantago major L.

Analgesic and antiinflammatory activities of the aqueous extract of Plantago major L.

Author Guillen Nunez, Maria Elena Autor UNIFESP Google Scholar
Emim, Jose Artur da Silva Autor UNIFESP Google Scholar
Souccar, Caden Autor UNIFESP Google Scholar
Lapa, Antonio José Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract This study aimed to validate the pharmacological effects of Plantago major L., a medicinal plant used to decrease pain and inflammation. The aqueous extract (AE) was prepared from the dried ground leaves. Pretreatment with AE (1 g/kg, p.o.) decreased writhing induced by acetic acid in mice but it did not change the tail Pick responses to heat nociceptive stimuli. In rats, AE (1 g/kg, p.o.) reduced the paw edema and pleurisy induced by carrageenin, but it did not alter the paw edema induced by dextran. The effect of AE on the carrageenin inflammatory responses was more intense than that obtained on the ear edema induced by croton oil in mice. In addition, daily treatment with AE (1 g/kg/day during 8 days, p.o.) inhibited the exudative process induced by croton oil injected into the air pouch of rats. The results indicate that the aqueous extract of Plantago major is endowed with effective antiinflammatory and analgesic activities.
Keywords analgesic
antiinflammatory activity
Plantago major L.
medicinal plant
Language English
Date 1997-04-01
Published in International Journal Of Pharmacognosy. Lisse: Swets Zeitlinger Publishers, v. 35, n. 2, p. 99-104, 1997.
ISSN 0925-1618 (Sherpa/Romeo, impact factor)
Publisher Swets Zeitlinger Publishers
Extent 99-104
Access rights Closed access
Type Article
Web of Science ID WOS:000071162400004

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