Low-grade sarcoma in classical seminoma - the first case reported

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Data
2010-01-01
Autores
Petersson, Fredrik
Michal, Michal
Grossmann, Petr
Franco, Marcello Fabiano de [UNIFESP]
Zamecnik, Michal
Hes, Ondrej
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A 30-year-old male with no previous history of neoplastic disease presented with a 5 cm large testicular tumor. Routine histopathological examination and immunohistochemical investigation showed a classical seminoma with a contiguous 8 mm large nodule. The nodule was separated from the tunica albuginea by tubuli semi-niferi showing intratesticular germ cell neoplasi not otherwise specified (NOS). The nodule was composed of spindle cells with low-grade nuclear atypia, nuclear and cytoplasmic S100 protein immunoreactivity in 15% of the cells and a proliferative activity of up to 20%. No other germ cell tumor components were found. To the best of our knowledge, we herein present the first tumor of a pure classical seminoma with an associated low-grade sarcomatous component.
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International Journal Of Clinical And Experimental Pathology. Madison: E-century Publishing Corp, v. 3, n. 2, p. 203-209, 2010.
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