In Vivo Models for Measuring Placental Glutatione-S-transferase (GST-P 7-7) Levels: A Suitable Biomarker for Understanding Cancer Pathogenesis

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dc.contributor.author Noguti, Juliana [UNIFESP]
dc.contributor.author Barbisan, Luis Fernando
dc.contributor.author Cesar, Augusto [UNIFESP]
dc.contributor.author Pereira, Camilo Dias Seabra [UNIFESP]
dc.contributor.author Choueri, Rodrigo Brasil [UNIFESP]
dc.contributor.author Ribeiro, Daniel Araki [UNIFESP]
dc.date.accessioned 2018-06-15T17:38:31Z
dc.date.available 2018-06-15T17:38:31Z
dc.date.issued 2012-07-01
dc.identifier http://iv.iiarjournals.org/content/26/4/647.full
dc.identifier.citation In Vivo. Athens: Int Inst Anticancer Research, v. 26, n. 4, p. 647-650, 2012.
dc.identifier.issn 0258-851X
dc.identifier.uri http://repositorio.unifesp.br/11600/43917
dc.description.abstract The Glutatione-S-transferases (GSTs) comprise a family of enzymes closely associated with the cell detoxification of xenobiotics. GSTs exist as homo- or heterodimers and have been grouped into at least seven distinct classes. The main function of GSTs is to catalyze the conjugation of reduced glutathione (GSH) to an electrophilic site of a broad range of potentially toxic and carcinogenic compounds, thereby making such compounds less dangerous and enabling their ready-excretion. Placental GST, known as GST-P 7-7, is the main isoform found in normal placental tissue and comprises 67% of the total GST concentration in this tissue. During development, GST-P 7-7 decreases in concentration and is absent in adult tissues. Interestingly, GST-P 7-7 expression has been detected in adult tissues after exposure to carcinogenic agents in several experimental test systems, being considered a reliable biomarker of exposure and susceptibility in early phases of carcinogenesis. In this article, we review a series of studies involving GST-P 7-7 expression as a suitable tool for understanding cancer pathogenesis, especially cancer risk. en
dc.format.extent 647-650
dc.language.iso eng
dc.publisher Int Inst Anticancer Research
dc.relation.ispartof In Vivo
dc.rights Acesso aberto
dc.subject Cancer en
dc.subject in vivo models en
dc.subject GST-P 7-7 en
dc.subject review en
dc.title In Vivo Models for Measuring Placental Glutatione-S-transferase (GST-P 7-7) Levels: A Suitable Biomarker for Understanding Cancer Pathogenesis en
dc.type Resenha
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade de São Paulo (USP)
dc.description.affiliation Univ Fed Sao Paulo, Univ Fed Sao Paulo, Dept Biosci, Sao Paulo, SP, Brazil
dc.description.affiliation Univ Fed Sao Paulo, Univ Fed Sao Paulo, Dept Pathol, Sao Paulo, SP, Brazil
dc.description.affiliation UNESP, Sao Paulo State Univ, Dept Morphol, Inst Biosci, Botucatu, SP, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Univ Fed Sao Paulo, Dept Biosci, Sao Paulo, SP, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Univ Fed Sao Paulo, Dept Pathol, Sao Paulo, SP, Brazil
dc.description.source Web of Science
dc.identifier.wos WOS:000306397000018



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