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dc.contributor.authorCaseiro, Marcos Montani
dc.contributor.authorGolegã, Alcino A.c.
dc.contributor.authorEtzel, Arnaldo
dc.contributor.authorDiaz, Ricardo Sobhie [UNIFESP]
dc.date.accessioned2015-06-14T13:38:34Z
dc.date.available2015-06-14T13:38:34Z
dc.date.issued2008-06-01
dc.identifierhttp://dx.doi.org/10.1590/S1413-86702008000300001
dc.identifier.citationBrazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 12, n. 3, p. 162-166, 2008.
dc.identifier.issn1413-8670
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/4387
dc.description.abstractWe characterized the virologic failure after an initially successful 48-week course of antiretroviral therapy among HIV/AIDS patients in a retrospective cohort study involving patients from Santos, Brazil. Patients with plasma HIV RNA below 500 copies/mL for 48 weeks were included. Variables analyzed included gender, age, level of education, marital status, mode of HIV acquisition, viral load, and CD4 cell count upon admission. There were 4,909 patients registered with the clinic, of which 669 patients met all the inclusion criteria (41.6% female and 58.4% male). Only 27.5% of the patients maintained undetectable viral loads during up to one year of follow-up. After 48 weeks, virologic failure occurred earlier in females and in patients first treated with an antiretroviral regimen other than highly active antiretroviral therapy. Patients who were married or had a steady partner experienced virologic failure later than did those who were separated or widowed. The percentage of public health clinic patients who maintain undetectable viral loads for a period of over a year is much lower than that observed among patients enrolled in clinical trials. Females, individuals in unstable relationships, single individuals and widowed individuals should be given special attention in order to improve durability of viral suppression.en
dc.format.extent162-166
dc.language.isoeng
dc.publisherBrazilian Society of Infectious Diseases
dc.relation.ispartofBrazilian Journal of Infectious Diseases
dc.rightsAcesso aberto
dc.subjectAntiretroviral therapyen
dc.subjectvirologic failureen
dc.subjectHIVen
dc.subjectBrazilen
dc.titleCharacterization of virologic failure after an initially successful 48-week course of antiretroviral therapy in HIV/AIDS outpatients treated in Santos, Brazilen
dc.typeArtigo
dc.contributor.institutionFundação Lusiadas
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationFundação Lusiadas
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina (EPM)
dc.description.affiliationUnifespUNIFESP, EPM
dc.identifier.fileS1413-86702008000300001.pdf
dc.identifier.scieloS1413-86702008000300001
dc.identifier.doi10.1590/S1413-86702008000300001
dc.description.sourceSciELO
dc.identifier.wosWOS:000259751400001


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