FAMILIAL HYPERTENSION AND ALBUMINURIA IN NORMOTENSIVE TYPE-I DIABETIC-PATIENTS

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dc.contributor.author Freire, Maria Beatriz Sayeg [UNIFESP]
dc.contributor.author Ferreira, Sandra Roberta Gouvea [UNIFESP]
dc.contributor.author Vivolo, Marco Antonio [UNIFESP]
dc.contributor.author Oliveira, J. M.
dc.contributor.author Zanella, Maria Teresa [UNIFESP]
dc.date.accessioned 2018-06-15T17:35:11Z
dc.date.available 2018-06-15T17:35:11Z
dc.date.issued 1994-01-01
dc.identifier https://doi.org/10.1161/01.HYP.23.1_Suppl.I256
dc.identifier.citation Hypertension. Dallas: Amer Heart Assoc, v. 23, n. 1, p. I256-I258, 1994.
dc.identifier.issn 0194-911X
dc.identifier.uri http://repositorio.unifesp.br/11600/43819
dc.description.abstract An inherited predisposition to hypertension may increase susceptibility to nephropathy in type I diabetes. We evaluated the influence of a family history of essential hypertension on albuminuria in normotensive, normoalbuminuric type I diabetic patients. Forty-two diabetics (12.9+/-2.04 years) were divided into three groups according to tertiles of albumin excretion rate (group 1, 1.27+/-0.35; group 2, 2.43+/-0.49; group 3, 6.37+/-3.43 mu g/min; P<.001). Familial hypertension was considered to be present if the patient had one parent or grandparent on antihypertensive therapy. The three groups did not differ concerning age, diabetes duration, insulin requirement, body mass index, blood pressure, and urinary glucose excretion. Albumin excretion rate did not correlate with any parameter studied. The frequency of hypertension was significantly lower among the relatives of the patients from group 1 compared with those from groups 2 and 3 (28.6% versus 64.3% versus 78.6%, P<.03). Our data suggest that a familial antecedent of hypertension in normoalbuminuric type I diabetic patients is associated with a high normal albumin excretion rate not related to increases in blood pressure. Early changes in renal hemodynamics, seen in patients with a predisposition to hypertension, may contribute to increments in albuminuria even within the normal range. en
dc.format.extent I256-I258
dc.language.iso eng
dc.publisher Amer Heart Assoc
dc.relation.ispartof Hypertension
dc.rights Acesso aberto
dc.subject DIABETES MELLITUS, INSULIN-DEPENDENT en
dc.subject HYPERTENSION, ESSENTIAL en
dc.subject ALBUMINURIA en
dc.subject DIABETIC NEPHROPATHIES en
dc.title FAMILIAL HYPERTENSION AND ALBUMINURIA IN NORMOTENSIVE TYPE-I DIABETIC-PATIENTS en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution FAC MED JUNDIAI
dc.contributor.institution Universidade Federal Fluminense (UFF)
dc.description.affiliation ESCOLA PAULISTA MED,DEPT PREVENT MED,BR-04023 SAO PAULO,SP,BRAZIL
dc.description.affiliation FAC MED JUNDIAI,DEPT INTERNAL MED,SAO PAULO,SP,BRAZIL
dc.description.affiliation UNIV FED FLUMINENSE,DIV NEPHROL,RIO JANEIRO,BRAZIL
dc.description.affiliation ESCOLA PAULISTA MED,DIV ENDOCRINOL,SAO PAULO,SP,BRAZIL
dc.description.affiliationUnifesp ESCOLA PAULISTA MED,DEPT PREVENT MED,BR-04023 SAO PAULO,SP,BRAZIL
dc.description.affiliationUnifesp ESCOLA PAULISTA MED,DIV ENDOCRINOL,SAO PAULO,SP,BRAZIL
dc.identifier.doi 10.1161/01.HYP.23.1_Suppl.I256
dc.description.source Web of Science
dc.identifier.wos WOS:A1994MR84300055



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