The role of proteoglycans in the reactive stroma on tumor growth and progression

The role of proteoglycans in the reactive stroma on tumor growth and progression

Author Coulson-Thomas, Yvette May Autor UNIFESP Google Scholar
Ferreira, Tarsis Gesteira Autor UNIFESP Google Scholar
Norton, Andrew Lawrence Google Scholar
Kao, Winston W-Y Google Scholar
Nader, Helena Bonciani Autor UNIFESP Google Scholar
Coulson-Thomas, Vivien Jane Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Cincinnati
Univ Durham
Abstract The stroma surrounding tumors can either restrict or promote tumor growth and progression, and both the cellular and non-cellular components of the stroma play an active role. The cellular components in the surrounding stroma include tumor-associated fibroblasts, host tissue cells and immune cells. The noncellular components, which form the extracellular matrix (ECM) scaffold, include proteoglycans, collagen, proteinases, growth factors and cytokines. For tumorigenesis to occur it is necessary for tumor cells to modify the surrounding stroma. Tumor cells have mechanisms for achieving this, such as co-opting fibroblasts and modifying the ECM they produce, degrading the surrounding ECM and/or synthesizing a favorable ECM to support invasion. Proteoglycans are an important component of the ECM and play an active role in tumor growth and progression. The expression and glycosylation patterns of proteoglycans are altered in the stroma surrounding tumors and these molecules may support or restrict tumor growth and progression depending on the type and stage of tumor. In the present review we discuss the difference between the tumor promoting and restricting stromal reactions surrounding tumors and the role proteoglycans play.
Keywords Proteoglycans
Small leucine-rich proteoglycans
Tumor stroma
Tumor progression
Desmoplasia
Shedding
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Date 2015-01-01
Published in Histology And Histopathology. Murcia: F Hernandez, v. 30, n. 1, p. 33-41, 2015.
ISSN 0213-3911 (Sherpa/Romeo, impact factor)
Publisher F Hernandez
Extent 33-41
Origin http://doi.org/10.14670/HH-30.33
Access rights Open access Open Access
Type Review
Web of Science ID WOS:000346152600003
URI http://repositorio.unifesp.br/11600/43792

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