Effects of cimetidine and pentagastrin on surgical repair of gastric mucosa

Effects of cimetidine and pentagastrin on surgical repair of gastric mucosa

Author Giovanoni, Marisa Autor UNIFESP Google Scholar
Hayashi, C. Google Scholar
Hayashi, Hisakazu Autor UNIFESP Google Scholar
Freymüller-Haapalainen, Edna Autor UNIFESP Google Scholar
Geocze, Stephan Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract BACKGROUND/AIMS: The aim of this work is to evaluate the repair of mucosal epithelium at the critical time of the beginning of reepithelization of stomach wound.METHODOLOGY: Structural and ultrastructural evaluation of rat gastric mucosa repair was carried out with administration of placebo, cimetidine and pentagastrin in different groups of rats (Rattus norvegicus albinus) during the first 7 post-operative days. Following 48 hours of starvation and anesthesia by ethyl ether inhalation, the animals were submitted to laparotomy exposing the stomach. A fusiform gastric resection measuring 5mm in length was performed in the fundus stomach wall. The surgical wound was sutured in 2 plans: muscular tunic and visceral serosa. The abdominal wall was also sutured in 2 plans: parietal serosa-abdominal musculature and skin. During 6 consecutive post-operative days, the placebo group rats received 1ml of distilled water intragastrically; those of the cimetidine group 10mg/kg of cimetidine; and, animals of the pentagastrin group, 250 mu g/kg of pentagastrin by intraperitoneal injection. On the 7th post-operative day, rats were killed and fragments of the stomach wall containing transverse section of surgical wound were collected and processed for light microscopy and electron microscopies.RESULTS: At the beginning of gastric mucosal wound reepithelization cimetidine has better effect than that of pentagastrin.CONCLUSIONS: Comparative mucosal morphology showed that cimetidine tends to accelerate the beginning of reepithelization of granulation tissue while pentagastrin delays reepithelization due to alteration of protective mucus and a provoking increase of granulation tissue.
Keywords gastric mucosa
gastric surgery
cimetidine
pentagastrin
Language English
Date 1999-01-01
Published in Hepato-gastroenterology. Athens: H G E Update Medical Publ Ltd., v. 46, n. 25, p. 574-583, 1999.
ISSN 0172-6390 (Sherpa/Romeo, impact factor)
Publisher H G E Update Medical Publ Ltd.
Extent 574-583
Access rights Closed access
Type Article
Web of Science ID WOS:000079268000109
URI http://repositorio.unifesp.br/11600/43773

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