IMMUNOSUPPRESSIVE EFFECTS OF ALLOGENEIC BLOOD-TRANSFUSIONS - IMPLICATIONS FOR THE PATIENT WITH A MALIGNANCY
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Data
1995-02-01
Autores
Bordin, Jose Orlando [UNIFESP]
Blajchman, Morris A.
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Allogeneic blood transfusions (ABT) are associated with immunomodulatory effects to the recipients. Perioperative ABT thus may adversely affect overall prognosis in patients with a malignancy. ABT have been shown to be associated also with an increased risk for bacterial infections. In animal models, the ABT tumor growth-promoting effect has been shown to be related to leukocytes and is ameliorated by leukodepletion. In humans, such an effect has been reported; however, clearcut clinical evidence for the tumor growth-promoting effect of ABT has not yet been proved.
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Hematology-oncology Clinics Of North America. Philadelphia: W B Saunders Co, v. 9, n. 1, p. 205-218, 1995.