End results of a prospective trial on elective lateral neck dissection vs type III modified radical neck dissection in the management of supraglottic and transglottic carcinomas

End results of a prospective trial on elective lateral neck dissection vs type III modified radical neck dissection in the management of supraglottic and transglottic carcinomas

Author Brentani, Ricardo Renzo Autor UNIFESP Google Scholar
Kowalski, Luiz Paulo Autor UNIFESP Google Scholar
Soares, Jose F. Google Scholar
Torloni, Humberto Google Scholar
Pereira, Raimunda N. Google Scholar
Ikeda, Mauro Kasuo Autor UNIFESP Google Scholar
Andrade, Roberto Paulo de Autor UNIFESP Google Scholar
Magrin, Jose Autor UNIFESP Google Scholar
Miguel, Roberto EV Google Scholar
Santos, Carlos R. Google Scholar
Saba, Leda MB Google Scholar
Salvajoli, João Victor Autor UNIFESP Google Scholar
Curado, Maria P. Google Scholar
Oliveira, Jose C. Google Scholar
Montandon, Paula O. Google Scholar
Machado, Marcio M. Google Scholar
Denofrio, Giovana F. Google Scholar
Quinta, Waldyr C. Google Scholar
Alvarez, Rene B. Google Scholar
Alencar, Rita CG Google Scholar
Oliveira, Benedito V. Google Scholar
Ramos, Gil Google Scholar
Antunes, Lysandro S. Google Scholar
Andrade Sobrinho, Josias de Autor UNIFESP Google Scholar
Rapoport, Abrão Autor UNIFESP Google Scholar
Carvalho, Marcos B. Google Scholar
Fava, Antônio S. Google Scholar
Gois Filho, Jose Francisco de Autor UNIFESP Google Scholar
Chagas, José Francisco de Sales Autor UNIFESP Google Scholar
Kanda, Jossi Ledo Autor UNIFESP Google Scholar
Gripp, Flavio M. Google Scholar
Ribas, Marcelo H. Google Scholar
Castro, Ivan S. Google Scholar
Oliveira, Joni MS Google Scholar
Oliveira, Jose AM Google Scholar
Carvalho, Ricardo C. Google Scholar
Araujo, Laercio B. Google Scholar
Pontes, Paulo Augusto de Lima Autor UNIFESP Google Scholar
Gregório, Luiz Carlos Autor UNIFESP Google Scholar
Abrahão, Márcio Autor UNIFESP Google Scholar
Cervantes, Onivaldo Autor UNIFESP Google Scholar
Paiva, Marcos Bandiera Autor UNIFESP Google Scholar
Hebbel, Werner S. Autor UNIFESP Google Scholar
Fujita, Reginaldo Raimundo Autor UNIFESP Google Scholar
Motta, Pedro HH Autor UNIFESP Google Scholar
Segreto, Roberto Araujo Autor UNIFESP Google Scholar
Camargo, Roberto S. Google Scholar
Menten, Marcos S. Google Scholar
Ferreira, Eugenio AB Google Scholar
Chassot, Celson Google Scholar
Brazilian Head Neck Canc Study Grp Google Scholar
Institution Ludwig Inst Canc Res
Hosp A C Camargo
Hosp Araujo Jorge
Hosp Erasto Gaertner
Hosp Heliopolis
Hosp Napoleao Laureano
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract Background. Either-modified type III radical neck dissection (MRND) or lateral neck dissections (LNDs) are considered valid treatments for patients with laryngeal carcinoma with clinically negative neck findings (NO). The object of this prospective study was to compare complications, neck recurrences, and survival results of elective MRND and LND on the management of laryngeal cancer patients.Patients and Methods. This prospective randomized study began in 1990, and patient accrual was closed on December 1993. A total of 132 patients was included in the trial. All patients had previously untreated T2-T4 NO MO supraglottic or transglottic squamous cell carcinoma. No significant imbalance was found between groups with respect to demographic, clinical, pathologic, and other therapeutic variables. Seventy-one patients were given MRNDs (13 bilateral) and 61 were given LNDs (18 bilateral).Results. The false-negative rate was 26%, and most positive nodes were sited at levels II and III. Complications and period of hospitalization were similar in both groups. There were 6 ipsilateral neck recurrences (4 in the MRND group, and 2 in the LND group). The 5-year actuarial survival calculated by Kaplan-Meier method was 72.3% in the MRND group and 62.4% in the LND group (log-rank test p = .312).Conclusions. The rate of false-negative nodes in supraglottic and transglottic carcinomas was 26%, and most positive nodes were at levels II and III. The rates of 5-year overall survival, neck recurrences, and complications were similar in both groups. These results confirm the efficacy of lateral neck dissection in the elective treatment of the neck in patients with supraglottic and transglottic carcinomas. (C) 1999 John Wiley & Sons, Inc. Head Neck 21: 694-702, 1999.
Keywords laryngeal cancer
neck dissections
clinical trial
survival analysis
Language English
Date 1999-12-01
Published in Head And Neck-journal For The Sciences And Specialties Of The Head And Neck. Hoboken: Wiley-blackwell, v. 21, n. 8, p. 694-702, 1999.
ISSN 1043-3074 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 694-702
Origin https://doi.org/10.1002/(SICI)1097-0347(199912)21:8<694
Access rights Closed access
Type Article
Web of Science ID WOS:000083844700002
URI http://repositorio.unifesp.br/11600/43741

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