Relationship between angiogenesis and grade of histologic differentiation in endometrial adenocarcinoma

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Speck, Neila Maria de Góis [UNIFESP]
Focchi, José [UNIFESP]
Alves, A. C.
Ribalta, Julisa Chamorro Lascasas [UNIFESP]
Osório, Cintia Aparecida Bueno [UNIFESP]
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The objective of the study was to quantity vessels and to relate them to the degree of histologic differentiation in endometrial adenocarcinoma. We studied 35 cases of which ten were G1, 13 G2 and 12 G3 adenocarcinonias. The control group consisted of 11 atrophic and 10 proliferative endometria. From each case two histologic sections were obtained: one for hematoxylin-eosin staining and the other for immunohistochemical study with anti-CD34. Vessel count was performed by morphometric study. Mean vessel count was 15.3 for G 1: 19 for G2 and 22.7 for G3 adenocarcinomas; in the control group it was 11.6 for atrophic and 13.2 for proliferative endometria. Slightly differentiated adenocarcinoma presented greater angiogenesis than normal and well-differentiated carcinoma. In contrast. moderately differentiated carcinoma showed greater angiogenicity as related to normal endometrium, but did not differ from other tumoral endometria.
European Journal Of Gynaecological Oncology. Montreal: I R O G Canada, Inc, v. 26, n. 6, p. 599-601, 2005.