Amygdala kindling in Proechimys guyannensis rat: An animal model of resistance to epilepsy
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2003-02-01
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Carvalho, R. D.
Arida, Ricardo Mario [UNIFESP]
Cavalheiro, Esper Abrão [UNIFESP]
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Purpose: This study examined the effect of amygdala kindling development in Proechimys guayannensis rat, a common rodent of the Amazon basin.Methods: Adult male P. guayannensis animals (n = 43) and adult male Wistar rats (n = 14) were submitted to electrical amygdala kindling.Results: From 43 Proechimys rats submitted to the kindling process, only three animals reached stage 5 of kindling. During the kindling development (stages 4-5), these animals had behavioral alterations different from those observed in Wistar rats. A longer time spent in stages 1-3 and 5 and longer after discharge duration in stages 1-4 was observed in the Proechimys group compared with the Wistar group. The number of wet-dog shakes also was reduced in the Proechimys group during the kindling process.Conclusions: These findings suggest natural endogenous inhibitory mechanisms in this animal species.
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Epilepsia. Hoboken: Wiley-blackwell, v. 44, n. 2, p. 165-170, 2003.