CEFETAMET PIVOXIL IN THE TREATMENT OF COMMUNITY-ACQUIRED PNEUMONIA IN CHILDREN

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dc.contributor.author Syrogiannopoulos, G. A.
dc.contributor.author Chibante, AMD
dc.contributor.author Gatzola, M.
dc.contributor.author Toporovski, J.
dc.contributor.author Madrid, B.
dc.contributor.author Farhat, Calil Kairalla [UNIFESP]
dc.contributor.author Fall, M.
dc.contributor.author Burgio, G. R.
dc.contributor.author Likitnukul, S.
dc.contributor.author Kissling, M.
dc.date.accessioned 2018-06-15T17:17:25Z
dc.date.available 2018-06-15T17:17:25Z
dc.date.issued 1994-07-01
dc.identifier https://doi.org/10.1007/BF03257424
dc.identifier.citation Drug Investigation. Auckland: Adis International Ltd, v. 8, n. 1, p. 31-37, 1994.
dc.identifier.issn 0114-2402
dc.identifier.uri http://repositorio.unifesp.br/11600/43499
dc.description.abstract The efficacy and safety of cefetamet pivoxil in the treatment of community-acquired pneumonia in children were assessed in an open, randomised, comparative multicentre study in which 260 children (in- and outpatients) with either bacterial pneumonia (n = 170) or bronchopneumonia (n = 90) were enrolled. Cefetamet pivoxil, an oral third generation cephalosporin, was administered to 85 children at a dosage of 10 mg/kg twice daily, the recommended therapeutic dosage, and to 94 children at a dosage of 20 mg/kg twice daily. Cefaclor was administered to 81 children at a dosage of 10 mg/kg three times daily. The duration of treatment was 7 days. Assessments were performed on days 0, 3, 7 and 14 after initiation of treatment. Clinical signs and symptoms began to improve soon after the start of treatment, and continued to improve in all 3 treatment groups. The therapeutic outcome was considered successful in 80 of the 81 assessable patients receiving cefetamet pivoxil 10 mg/kg twice daily (98.8%), in 79 of the 81 assessable patients receiving cefetamet pivoxil 20 mg/kg twice daily (97.6%), and in 71 of the 75 assessable patients receiving cefaclor 10 mg/kg three times daily (94.7%). The differences in outcome between the 3 groups were not statistically significant. Adverse events were of gastrointestinal origin (mainly diarrhoea, nausea, and/or vomiting), and occurred with similar frequencies in the groups treated with cefetamet pivoxil 10 mg/kg twice daily and cefaclor 10 mg/kg three times daily.Cefetamet pivoxil administered at the standard dosage of 10 mg/kg twice daily was effective and well tolerated in children with bacterial pneumonia or bronchopneumonia. The twice-daily cefetamet pivoxil dose schedule compares favourably with the well-established cefaclor 3-times-daily regimen and may result in improved compliance. en
dc.format.extent 31-37
dc.language.iso eng
dc.publisher Adis International Ltd
dc.relation.ispartof Drug Investigation
dc.rights Acesso restrito
dc.title CEFETAMET PIVOXIL IN THE TREATMENT OF COMMUNITY-ACQUIRED PNEUMONIA IN CHILDREN en
dc.type Artigo
dc.contributor.institution F HOFFMANN LA ROCHE & CO LTD
dc.contributor.institution UNIV HOSP PATRAS
dc.contributor.institution HOSP GAFFREE & GUINLE
dc.contributor.institution HOSP AHEPA
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution PHILIPPINES GEN HOSP
dc.contributor.institution POLICLIN SAN MATTEO
dc.contributor.institution CHULALONGKORN HOSP
dc.contributor.institution HOP LE DANTEC
dc.description.affiliation F HOFFMANN LA ROCHE & CO LTD,CLIN RES DEPT,CH-4002 BASEL,SWITZERLAND
dc.description.affiliation UNIV HOSP PATRAS,DEPT PEDIAT,PATRAI,GREECE
dc.description.affiliation HOSP GAFFREE & GUINLE,RIO JANEIRO,BRAZIL
dc.description.affiliation HOSP AHEPA,UNIV CLIN,DEPT PEDIAT,THESSALONIKI,GREECE
dc.description.affiliation FAC CIENCIAS MED SANTA CASA SAO PAULO,DEPT PEDIAT,SAO PAULO,BRAZIL
dc.description.affiliation PHILIPPINES GEN HOSP,DEPT PEDIAT,MANILA,PHILIPPINES
dc.description.affiliation HOSP SAO PAULO,SAO PAULO,BRAZIL
dc.description.affiliation POLICLIN SAN MATTEO,PAVIA,ITALY
dc.description.affiliation CHULALONGKORN HOSP,DEPT PEDIAT,BANGKOK,THAILAND
dc.description.affiliation HOP LE DANTEC,DAKAR,SENEGAL
dc.description.affiliationUnifesp HOSP SAO PAULO,SAO PAULO,BRAZIL
dc.identifier.doi 10.1007/BF03257424
dc.description.source Web of Science
dc.identifier.wos WOS:A1994NY65700004



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