Autoantibodies against glutamic acid decarboxylase and 21-hydroxylase in Brazilian patients with Type 1 diabetes or autoimmune thyroid diseases

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dc.contributor.author Silva, R. C.
dc.contributor.author Sallorenzo, Carolina [UNIFESP]
dc.contributor.author Kater, Claudio Elias [UNIFESP]
dc.contributor.author Dib, Sergio Atala [UNIFESP]
dc.contributor.author Falorni, A.
dc.date.accessioned 2018-06-15T17:17:23Z
dc.date.available 2018-06-15T17:17:23Z
dc.date.issued 2003-06-01
dc.identifier.citation Diabetes Nutrition & Metabolism. Milan: Editrice Kurtis S R L, v. 16, n. 3, p. 160-168, 2003.
dc.identifier.issn 0394-3402
dc.identifier.uri http://repositorio.unifesp.br/11600/43482
dc.description.abstract Autoimmune thyroid diseases (ATD) are often associated with Type 1 diabetes mellitus (T1DM) and Addison's disease (AD), characterizing the autoimmune polyendocrine syndrome. We evaluated the frequency of autoantibodies against glutamic acid decarboxylase isoform. 65 (GAD65Ab) and 21-hydroxylase (21OHAb) in the sera of 65 [58 females (F)/7 males (M), 17-70 yr] patients with Graves' disease (GD) and 47 (45 F/2 M, 12-77 yr) with Hashimoto's thyroiditis (HT), none of whom had either diabetes or AD. The sera of 30 recently diagnosed T1DM patients (16 M/14 F, 1-39 yr) and of 97 (54 F/43 M, 7-69 yr) healthy controls were also examined. GAD65Ab were detected in the sera of 18 (60%) T1DM, 8 (12%) GD and in none of the HT patients or the controls (p=0.03 for GD vs HT, p=0.002 for GD vs controls, and p<0.001 for GD vs T1DM). 21OHAb were detected in the sera of 2 (3%) GD, 1 (2%) HT and in none of the T1DM patients or the controls. GAD65Ab levels were significantly lower in GD than in T1DM patients (median: -0.06 vs 0.28,p<0.001). Six of the 8 GD GAD65Ab-positive patients submitted to an intravenous glucose tolerance test showed no diminished first phase insulin secretion. All 21OHAb positive patients had normal basal cortisol and adrenocorticotropin (ACTH), normal cortisol response after ACTH stimulation, but high plasma renin activity. In conclusion, despite the genetic diversity of the Brazilian population, the frequency of GAD65Ab and 21OHAb in our patients is similar to that observed in other countries. GAD65Ab were more prevalent in GD than in HT patients, suggesting a difference in the immune response between these disorders. Long-term follow-up is necessary to determine the clinical relevance of these autoantibodies in the Brazilian population. (C) 2003, Editrice Kurtis. en
dc.format.extent 160-168
dc.language.iso eng
dc.publisher Editrice Kurtis S R L
dc.relation.ispartof Diabetes Nutrition & Metabolism
dc.rights Acesso restrito
dc.subject Addison's disease en
dc.subject autoimmune polyendocrine syndromes en
dc.subject GAD65 en
dc.subject 21-hydroxylase en
dc.subject Graves' disease en
dc.subject Hashimoto's thyroiditis en
dc.title Autoantibodies against glutamic acid decarboxylase and 21-hydroxylase in Brazilian patients with Type 1 diabetes or autoimmune thyroid diseases en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Univ Perugia
dc.description.affiliation Univ Fed Sao Paulo, Div Endocrinol, Dept Med, BR-04034970 Sao Paulo, Brazil
dc.description.affiliation Univ Perugia, Dept Internal Med, Sect Endocrinol & Metab Sci, I-06100 Perugia, Italy
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Div Endocrinol, Dept Med, BR-04034970 Sao Paulo, Brazil
dc.description.source Web of Science
dc.identifier.wos WOS:000186244900004



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