Nitric Oxide Releasing Nanomaterials for Cancer Treatment: Current Status and Perspectives

Show simple item record Seabra, Amedea Barozzi [UNIFESP] Lima, Renata de Calderon, Marcelo 2018-06-15T17:05:16Z 2018-06-15T17:05:16Z 2015-01-01
dc.identifier.citation Current Topics In Medicinal Chemistry. Sharjah: Bentham Science Publ Ltd, v. 15, n. 4, p. 298-308, 2015.
dc.identifier.issn 1568-0266
dc.description.abstract Nitric oxide (NO) is known to have dichotomous effects on cancer biology, acting as a pro-or antineoplastic agent. Low concentrations of NO are reported to promote tumor growth, whereas high NO influx acts as a potent tumor repressor, leading to cytotoxicity and apoptosis. There is increasing interest in developing NO-releasing materials as potent tumoricidal agents in which high and localized concentrations of NO may be directly released in a sustained manner to the tumor site. Nanomaterials allied to NO donors have emerged as a promising strategy in cancer treatment. In this context, this review summarizes the roles of NO in cancer biology and highlights the therapeutic potential effects of NO-releasing nanomaterials based on polymeric nanoparticles, dendritic polymers, liposomes, silica nanoparticles, metallic nanoparticles and quantum dots in combating tumor cells. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship CONNECT Program of the Alexander von Humboldt Foundation
dc.description.sponsorship NanoMatFutur award (BMBF)
dc.description.sponsorship Focus Area Functional Materials at the Nanoscale of the Freie Universitat Berlin
dc.format.extent 298-308
dc.language.iso eng
dc.publisher Bentham Science Publ Ltd
dc.relation.ispartof Current Topics In Medicinal Chemistry
dc.rights Acesso restrito
dc.subject Cancer en
dc.subject Cytotoxicity en
dc.subject Dendrimers en
dc.subject Diazeniumdiolates en
dc.subject Liposomes en
dc.subject Metallic nanoparticles en
dc.subject Nanomaterials en
dc.subject Nitric Oxide en
dc.subject Polymeric nanoparticles en
dc.subject Quantum dots en
dc.subject Silica nanoparticles en
dc.subject S-nitrosothiols en
dc.title Nitric Oxide Releasing Nanomaterials for Cancer Treatment: Current Status and Perspectives en
dc.type Resenha
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Univ Sorocaba
dc.contributor.institution Free Univ Berlin
dc.description.affiliation Univ Fed Sao Paulo, Exact & Earth Sci Dept, BR-09913030 Diadema, SP, Brazil
dc.description.affiliation Univ Sorocaba, Dept Biotechnol, Sorocaba, SP, Brazil
dc.description.affiliation Free Univ Berlin, Inst Chem & Biochem, Berlin, Germany
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Exact & Earth Sci Dept, BR-09913030 Diadema, SP, Brazil
dc.description.sponsorshipID FAPESP: 2012/17053-7
dc.description.sponsorshipID NanoMatFutur award (BMBF): 13N12561
dc.identifier.doi 10.2174/1568026615666150108122918
dc.description.source Web of Science
dc.identifier.wos WOS:000351013200005


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