Nitric Oxide Releasing Nanomaterials for Cancer Treatment: Current Status and Perspectives

Nitric Oxide Releasing Nanomaterials for Cancer Treatment: Current Status and Perspectives

Author Seabra, Amedea Barozzi Autor UNIFESP Google Scholar
Lima, Renata de Google Scholar
Calderon, Marcelo Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Sorocaba
Free Univ Berlin
Abstract Nitric oxide (NO) is known to have dichotomous effects on cancer biology, acting as a pro-or antineoplastic agent. Low concentrations of NO are reported to promote tumor growth, whereas high NO influx acts as a potent tumor repressor, leading to cytotoxicity and apoptosis. There is increasing interest in developing NO-releasing materials as potent tumoricidal agents in which high and localized concentrations of NO may be directly released in a sustained manner to the tumor site. Nanomaterials allied to NO donors have emerged as a promising strategy in cancer treatment. In this context, this review summarizes the roles of NO in cancer biology and highlights the therapeutic potential effects of NO-releasing nanomaterials based on polymeric nanoparticles, dendritic polymers, liposomes, silica nanoparticles, metallic nanoparticles and quantum dots in combating tumor cells.
Keywords Cancer
Cytotoxicity
Dendrimers
Diazeniumdiolates
Liposomes
Metallic nanoparticles
Nanomaterials
Nitric Oxide
Polymeric nanoparticles
Quantum dots
Silica nanoparticles
S-nitrosothiols
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
CONNECT Program of the Alexander von Humboldt Foundation
NanoMatFutur award (BMBF)
Focus Area Functional Materials at the Nanoscale of the Freie Universitat Berlin
Grant number FAPESP: 2012/17053-7
NanoMatFutur award (BMBF): 13N12561
Date 2015-01-01
Published in Current Topics In Medicinal Chemistry. Sharjah: Bentham Science Publ Ltd, v. 15, n. 4, p. 298-308, 2015.
ISSN 1568-0266 (Sherpa/Romeo, impact factor)
Publisher Bentham Science Publ Ltd
Extent 298-308
Origin http://dx.doi.org/10.2174/1568026615666150108122918
Access rights Closed access
Type Review
Web of Science ID WOS:000351013200005
URI http://repositorio.unifesp.br/11600/43476

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