Plant Proteinases and Inhibitors: An Overview of Biological Function and Pharmacological Activity

Plant Proteinases and Inhibitors: An Overview of Biological Function and Pharmacological Activity

Author Gomes, Marco T. R. Google Scholar
Oliva, Maria Luiza Vilela Autor UNIFESP Google Scholar
Lopes, Miriam Teresa Paz Autor UNIFESP Google Scholar
Salas, Carlos E. Google Scholar
Institution Universidade Federal de Minas Gerais (UFMG)
Universidade Federal de São Paulo (UNIFESP)
Abstract Proteinases play a fundamental metabolic role during the life cycle in the plant kingdom. By interacting with endogenous or exogenous inhibitors, the proteolytic activity is modulated to meet metabolic requirements. By probing proteolytic enzymes with their inhibitors, it is possible to identify novel functions unrelated to their proteolytic activity. A group of plant proteolytic enzymes stands as a line of defence against environmental changes as their activation is triggered following various types of stress. On the other hand, plants also contain proteinase inhibitors as countermeasures for their protection against insects and pests. Both proteinases and inhibitors emerge as useful tools to combat human diseases. This review focuses on the biochemical characterization of plant proteinases, their inhibitors, the pharmacological potential of proteinases and inhibitors, and new putative emerging functions of proteolytically inhibited proteinases.
Keywords Antitumor activity
biological function
inhibitors
pharmacological activity
plant proteases
proteolytic activity
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Date 2011-08-01
Published in Current Protein & Peptide Science. Sharjah: Bentham Science Publ Ltd, v. 12, n. 5, p. 417-436, 2011.
ISSN 1389-2037 (Sherpa/Romeo, impact factor)
Publisher Bentham Science Publ Ltd
Extent 417-436
Origin http://dx.doi.org/10.2174/138920311796391089
Access rights Closed access
Type Review
Web of Science ID WOS:000294414500009
URI http://repositorio.unifesp.br/11600/43470

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