The Role of Mitochondrial Function in Glutamate-Dependent Metabolism in Neuronal Cells

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dc.contributor.author Smaili, Soraya Soubhi [UNIFESP]
dc.contributor.author Ureshino, Rodrigo Portes [UNIFESP]
dc.contributor.author Rodrigues, L. [UNIFESP]
dc.contributor.author Rocha, Katiucha Karolina [UNIFESP]
dc.contributor.author Carvalho, J. T. [UNIFESP]
dc.contributor.author Oseki, Karen Tubono [UNIFESP]
dc.contributor.author Bincoletto, Claudia [UNIFESP]
dc.contributor.author Lopes, Guiomar Silva [UNIFESP]
dc.contributor.author Hirata, Hanako [UNIFESP]
dc.date.accessioned 2018-06-15T17:05:15Z
dc.date.available 2018-06-15T17:05:15Z
dc.date.issued 2011-12-01
dc.identifier http://dx.doi.org/10.2174/138161211798357782
dc.identifier.citation Current Pharmaceutical Design. Sharjah: Bentham Science Publ Ltd, v. 17, n. 35, p. 3865-3877, 2011.
dc.identifier.issn 1381-6128
dc.identifier.uri http://repositorio.unifesp.br/11600/43466
dc.description.abstract Glutamate is an important neurotransmitter in neurons and glial cells and it is one of the keys to the neuron-glial interaction in the brain. Glutamate transmission is strongly dependent on calcium homeostasis and on mitochondrial function. In the present work we presented several aspects related to the role of mitochondria in glutamate signaling and in brain diseases. We focused on glutamate-induced calcium signaling and its relation to the organelle dysfunction with cell death processes. In addition, we have discussed how alterations in this pathway may lead or aggravate a variety of neurodegenerative diseases. We compiled information on how mitochondria can influence cell fate during glutamate stimulation and calcium signaling. These organelles play a pivotal role in neuron and glial exchange, in synaptic plasticity and several pathological conditions related to Aging, Alzheimer's, Parkinson's and Huntington's diseases. We have also presented autophagy as a mechanism activated during mitochondrial dysfunction which may function as a protective mechanism during injury. Furthermore, some new perspectives and approaches to treat these neurodegenerative diseases are offered and evaluated. en
dc.format.extent 3865-3877
dc.language.iso eng
dc.publisher Bentham Science Publ Ltd
dc.relation.ispartof Current Pharmaceutical Design
dc.rights Acesso restrito
dc.subject Glutamate en
dc.subject Calcium Signaling en
dc.subject Mitochondrial Dysfunction en
dc.subject Autophagy en
dc.subject Apoptosis en
dc.subject Cell Death en
dc.title The Role of Mitochondrial Function in Glutamate-Dependent Metabolism in Neuronal Cells en
dc.type Resenha
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ Fed Sao Paulo EPM UNIFESP, Dept Farmacol, Escola Paulista Med, Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo EPM UNIFESP, Dept Farmacol, Escola Paulista Med, Sao Paulo, Brazil
dc.identifier.doi 10.2174/138161211798357782
dc.description.source Web of Science
dc.identifier.wos WOS:000299637300006



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