Novel Vitreous Modulators for Pharmacologic Vitreolysis in the Treatment of Diabetic Retinopathy

Novel Vitreous Modulators for Pharmacologic Vitreolysis in the Treatment of Diabetic Retinopathy

Author Costa, Elaine de Paula Fiod Autor UNIFESP Google Scholar
Rodrigues, Eduardo Buchele Autor UNIFESP Google Scholar
Farah, Michel Eid Autor UNIFESP Google Scholar
Sebag, Jerry Google Scholar
Meyer, Carsten H. Autor UNIFESP Google Scholar
Institution Univ Bonn
Universidade Federal de São Paulo (UNIFESP)
VMR Inst
Univ So Calif
Abstract Vitreous constitutes about 80% of the volume of the human eye. It is an extended extracellular matrix that is composed of collagen, hyaluronan, and other extracellular matrix molecules, but mostly water. In both health as well as disease, especially diabetic retinopathy (DR), special attention should be drawn to the posterior vitreous cortex and its relation to the retinal surface. The important role of vitreous in the pathogenesis of proliferative DR has already been demonstrated by several experimental and clinical studies. Thus, vitreoretinal separation by pharmacologic vitreolysis and/or removal by surgical means are appropriate approaches to interrupt the pathogenic contribution of vitreous and prevent progression of diabetic retinopathy to more advanced stages. This review describes various aspects of the molecular morphology and structural anatomy of vitreous and the vitreoretinal interface, as well as the role of vitreous in the pathophysiology of DR. Lastly, this treatise provides a comprehensive analysis of novel vitreous modulators for pharmacologic vitreolysis in the treatment of DR. Microplasmin is currently the most promising approach to treat vitreoretinal traction by pharmacologic vitreolysis.
Keywords Diabetes
diabetic retinopathy
vitreous
diabetic vitreopathy
pharmacologic vitreolysis
Language English
Date 2011-03-01
Published in Current Pharmaceutical Biotechnology. Sharjah: Bentham Science Publ Ltd, v. 12, n. 3, p. 410-422, 2011.
ISSN 1389-2010 (Sherpa/Romeo, impact factor)
Publisher Bentham Science Publ Ltd
Extent 410-422
Origin http://dx.doi.org/10.2174/138920111794480516
Access rights Closed access
Type Review
Web of Science ID WOS:000288983300012
URI http://repositorio.unifesp.br/11600/43464

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