In Vitro Evaluation of Chloroaluminum Phthalocyanine Nanoemulsion and Low-Level Laser Therapy on Human Skin Dermal Equivalents and Bone Marrow Mesenchymal Stem Cells

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dc.contributor.author Primo, F. L.
dc.contributor.author Reis, M. B. da Costa [UNIFESP]
dc.contributor.author Porcionatto, Marimélia Aparecida [UNIFESP]
dc.contributor.author Tedesco, Antonio Claudio [UNIFESP]
dc.date.accessioned 2018-06-15T17:05:13Z
dc.date.available 2018-06-15T17:05:13Z
dc.date.issued 2011-08-01
dc.identifier http://dx.doi.org/10.2174/092986711796504745
dc.identifier.citation Current Medicinal Chemistry. Sharjah: Bentham Science Publ Ltd, v. 18, n. 22, p. 3376-3381, 2011.
dc.identifier.issn 0929-8673
dc.identifier.uri http://repositorio.unifesp.br/11600/43448
dc.description.abstract Nanotechnology and tissue engineering are promising scientific fields in the development of advanced materials useful to human health. This article describes the preparation of a nanocarrier for the controlled release of a photosensitizer compound associated with low-level light therapy for skin wound healing treatment and applicable to other skin diseases. A biological model was used as an in vitro skin equivalent based on a three-dimensional culture of fibroblasts and mesenchymal stem cells and denominated by dermal equivalent (DE). Results show that it is possible to use the photomodulation process to control the wound healing in a scratching process and to induce the biomolecules release, both of which are related with the inflammatory wound healing process. In the studies, the MMP-2 and MMP-9 expression from zymography analyses were evaluated. All results showed a dependence on enzymatic activity relating to low-level laser applications which indicates a potential application in wound healing processes based on phototherapy and nanotechnology. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent 3376-3381
dc.language.iso eng
dc.publisher Bentham Science Publ Ltd
dc.relation.ispartof Current Medicinal Chemistry
dc.rights Acesso restrito
dc.subject Dermal equivalents en
dc.subject mesenchymal stem cells en
dc.subject nanoemulsions en
dc.subject nanotechnology en
dc.subject phthalocyanine en
dc.subject tissue engineering en
dc.subject photodynamic process en
dc.subject human fibroblast en
dc.subject low-level laser therapy en
dc.subject matrix metalloproteinases en
dc.title In Vitro Evaluation of Chloroaluminum Phthalocyanine Nanoemulsion and Low-Level Laser Therapy on Human Skin Dermal Equivalents and Bone Marrow Mesenchymal Stem Cells en
dc.type Resenha
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Lab Fotobiol & Fotomed, Ctr Nanotecnol & Engn Tecidual,Dept Quim, BR-14040901 Ribeirao Preto, SP, Brazil
dc.description.affiliation Univ Fed Sao Paulo, Dept Bioquim, BR-04044020 Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Bioquim, BR-04044020 Sao Paulo, Brazil
dc.description.sponsorshipID FAPESP: 2009/15363-9
dc.description.sponsorshipID FAPESP: 2008/53719-4
dc.description.sponsorshipID FAPESP: 2007/55319-0
dc.description.sponsorshipID FAPESP: 2006/50562-1
dc.identifier.doi 10.2174/092986711796504745
dc.description.source Web of Science
dc.identifier.wos WOS:000294405600012



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