Photodynamic therapy with indocyanine green for occult subfoveal choroidal neovascularization caused by age-related macular degeneration

Photodynamic therapy with indocyanine green for occult subfoveal choroidal neovascularization caused by age-related macular degeneration

Author Costa, Rogerio Alves Autor UNIFESP Google Scholar
Farah, Michel Eid Autor UNIFESP Google Scholar
Cardillo, Jose Augusto Autor UNIFESP Google Scholar
Belfort, Rubens Junior Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Purpose. To report two cases of occult subfoveal choroidal neovascularization (CNV) due to age-related macular degeneration (AMD) that were successfully treated utilizing large spot, low irradiance 810-nm light and intravenous injection of small-volume, high-concentration indocyanine green (ICG) bolus, termed ICG-mediated photodynamic therapy (i-PDT).Methods. Case report. Two patients with occult subfoveal CNV (two eyes) due to AMD were treated with i-PDT and were prospectively followed with fluorescein and indocyanine green angiography as well as optical coherence tomography (OCT).Results. Both patients presented a 3-line increase in visual acuity by twelve months of follow-up. A significant regression of the CNV was demonstrated by fluorescein angiography within one week following treatment. OCT revealed diminishing of the subretinal fluid. There were no complications related to the procedure.Conclusion. i-PDT induced CNV regression and improved the visual acuity in these particular cases, suggesting a new and promising way to treat neovascular AMD. The partial anatomical restoration associated to the improvement of the visual function observed in both patients suggests that a selective therapeutic effect was achieved. Further studies are required not only to assess the clinical value of this treatment but also to better understand the major mechanism of action involving this novel treatment modality.
Keywords age-related macular degeneration
choroidal neovascularization
indocyanine green
photodynamic therapy
Language English
Date 2001-01-01
Published in Current Eye Research. Lisse: Swets Zeitlinger Publishers, v. 23, n. 4, p. 271-275, 2001.
ISSN 0271-3683 (Sherpa/Romeo, impact factor)
Publisher Swets Zeitlinger Publishers
Extent 271-275
Origin http://dx.doi.org/10.1076/ceyr.23.4.271.5449
Access rights Closed access
Type Article
Web of Science ID WOS:000174375200006
URI http://repositorio.unifesp.br/11600/43442

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