What is the optimal way to subdivide obsessive-compulsive disorder?

What is the optimal way to subdivide obsessive-compulsive disorder?

Author Mathis, Maria Alice de Autor UNIFESP Google Scholar
Diniz, Juliana Belo Google Scholar
Rosario, Maria Conceicao do Autor UNIFESP Google Scholar
Torres, Albina Rodrigues Autor UNIFESP Google Scholar
Hoexter, Marcelo Queiroz Autor UNIFESP Google Scholar
Hasler, Gregor Google Scholar
Miguel, Euripedes Constantino Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Univ Zurich Hosp
Abstract The clinical presentation of obsessive-compulsive disorder (OCD) varies not only across patients but over the course of the disorder. This diversity indicates that OCD is a heterogeneous disorder, which may have an important impact on psychopathological, longitudinal, genetic, and treatment research. To better understand OCD heterogeneity, more homogeneous phenotypic descriptions are necessary to delimiting clinically meaningful subgroups of patients. Besides phenotypic descriptions, another method of delimiting OCD patient subgroups includes the search for endophenotypes (extended phenotypes) based on neurophysiological, immunological, genetic, neuropsychological, or neuroanatomic (neuroimaging) paradigms. This article will describe some strategies that deal with OCD heterogeneity, including the identification of more homogeneous phenotypical categories, an improved understanding of obsessive-compulsive symptom dimensions and how to use them as quantitative traits, and broadening the diagnostic boundaries of OCD to include other related conditions. The relevance and limitations of each approach are also discussed. Since the etiological mechanisms associated with the expressions of OCD are unknown, there is probably not one but several heuristic strategies to search for more homogeneous OCD subgroup, that combined may provide the most fruitful results.
Language English
Date 2006-10-01
Published in Cns Spectrums. New York: M B L Communications, Inc, v. 11, n. 10, p. 762-779, 2006.
ISSN 1092-8529 (Sherpa/Romeo, impact factor)
Publisher M B L Communications, Inc
Extent 762-779
Origin https://doi.org/10.1017/S1092852900014899
Access rights Closed access
Type Review
Web of Science ID WOS:000241447100019
URI http://repositorio.unifesp.br/11600/43400

Show full item record


File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)




My Account