Treatment of early diffuse systemic sclerosis skin disease

Treatment of early diffuse systemic sclerosis skin disease

Author Frech, T. M. Google Scholar
Shanmugam, V. K. Google Scholar
Shah, A. A. Google Scholar
Assassi, S. Google Scholar
Gordon, J. K. Google Scholar
Hant, F. N. Google Scholar
Hinchcliff, M. E. Google Scholar
Steen, V. Google Scholar
Khanna, D. Google Scholar
Kayser, Cristiane Autor UNIFESP Google Scholar
Domsic, R. T. Google Scholar
Institution Univ Utah
Vet Affair Med Ctr
MedStar Georgetown Univ Hosp
Johns Hopkins Univ
Univ Texas Hlth Sci Ctr Houston
Hosp Special Surg
Med Univ S Carolina
Northwestern Univ
Georgetown Univ Hosp
Univ Michigan
Universidade Federal de São Paulo (UNIFESP)
Univ Pittsburgh
Abstract Diffuse systemic sclerosis carries a high morbidity and mortality. The Prospective Registry of Early Systemic Sclerosis (PRESS), a multicentre incident cohort study of patients with early diffuse cutaneous systemic sclerosis, has the goal of advancing the understanding of disease pathogenesis and identifying novel biomarkers. In this review, PRESS investigators discuss the evidence pertaining to the more commonly used treatments for early diffuse SSc skin disease including methotrexate, mycophenolate, cyclophospha-mide, azathioprine, and intravenous immuno globulin. This review high-lights the unmet need for effective treatment in early diffuse SSc as well as its more rigorous study. Nonetheless, the PRESS investigators aim to decrease intra- and inter-institutional variability in prescribing in order to improve the understanding of the clinical course of early diffuse SSc skin disease.
Keywords systemic sclerosis
scleroderma
skin disease
treatment
Language English
Sponsor National Center for Research Resources
National Center for Advancing Translational Sciences, National Institutes of Health
National Institute of Nursing Research
NIH/NIAMS
NIH NIAMS
Grant number National Center for Advancing Translational Sciences, National Institutes of Health: 8UL1TR000105
National Center for Research Resources: KL2RR031974
National Center for Research Resources: UL1RR031975
National Institute of Nursing Research: R01NR013888
NIH/NIAMS: K24 AR063120
NIH NIAMS: K23 AR057845
: K23 AR061439
: K23 AR061436
Date 2013-03-01
Published in Clinical And Experimental Rheumatology. Pisa: Clinical & Exper Rheumatology, v. 31, n. 2, p. S166-S171, 2013.
ISSN 0392-856X (Sherpa/Romeo, impact factor)
Publisher Clinical & Exper Rheumatology
Extent S166-S171
Origin http://www.clinexprheumatol.org/article.asp?a=6961
Access rights Open access Open Access
Type Review
Web of Science ID WOS:000330268000025
URI http://repositorio.unifesp.br/11600/43335

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