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dc.contributor.authorFontes, Tereza Maria Pereira [UNIFESP]
dc.contributor.authorSimoes, Ricardo Santos [UNIFESP]
dc.contributor.authorOliveira, F. H. Martins
dc.contributor.authorSimoes, Manuel de Jesus [UNIFESP]
dc.contributor.authorOliveira-Filho, Ricardo Martins [UNIFESP]
dc.contributor.authorNakamura, Mary Uchiyama [UNIFESP]
dc.contributor.authorKulay Júnior, Luiz [UNIFESP]
dc.identifier.citationClinical And Experimental Obstetrics & Gynecology. Montreal: I R O G Canada, Inc, v. 34, n. 3, p. 175-178, 2007.
dc.description.abstractThe purpose of the study was to evaluate at term, the effects of the association of zidovudine/ritonavir administered during the entire period of rat pregnancy. Forty pregnant EPM-1 Wistar rats were divided randomly into four groups: one control (drug vehicle control, n = 10) and three experimental treated with an oral solution of zidovudine/ritonavir (Exp 1 = 10/20 mg/kg bw, n = 10; Exp 2 = 30/60 mg/kg bw, n = 10; Exp 3 = 90/180 mg/kg bw, n = 10) from day 0 up to day 20 of pregnancy. Maternal body weights were recorded at the start of the experiment and at the 7(th), 14(th) and the 20(th) day thereafter. At term (20(th) day) the rats were anesthetized and, upon laparotomy and hysterotomy, the number of implantations, resorptions, living fetuses, placentae and intrauterine deaths were recorded. The collected fetuses and placentae were weighed, and the concepts were examined under a stereoscopic microscope for external malformations. The maternal body gain and the mean fetal weight at term were both significantly lower (p < 0.01 and p < 0.0001, respectively) in the experimental groups compared to the control. The recorded resorptions were higher in Exp 2 and Exp 3 groups than in the control group. The other parameters were not affected. The exposure of pregnant rats at term to a 1:2 association of zidovudine plus ritonavir resulted in a significant reduction in maternal body weight gain and increased rate of fetal resorption.en
dc.publisherI R O G Canada, Inc
dc.relation.ispartofClinical And Experimental Obstetrics & Gynecology
dc.rightsAcesso restrito
dc.titleExtended administration of the association of zidovudine plus ritonavir during rat pregnancy: maternal and fetal effectsen
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionFac Ciencias Med
dc.description.affiliationUniv Fed Sao Paulo, Sch Med UNIFESP EPM, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Inst Biomed Sci, Dept Pharmacol, Sao Paulo, Brazil
dc.description.affiliationFac Ciencias Med, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Sch Med UNIFESP EPM, Sao Paulo, Brazil
dc.description.sourceWeb of Science

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