EARLY IMMUNIZATION OF NEONATES WITH TRIVALENT ORAL POLIOVIRUS VACCINE
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1992-01-01
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Weckx, Lily Yin [UNIFESP]
Schmidt, Benjamin Jose [UNIFESP]
Herrmann, Herrmann, Anneliese A [UNIFESP]
Miyasaki, Celia Hatsuko [UNIFESP]
Novo, Neil Ferreira [UNIFESP]
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Described is the evaluation in Brazil of the immune response of early immunization with trivalent oral poliovirus vaccine (TOPV). A total of 85 normal neonates from Sao Paulo were assigned one of the following immunization schedules: group A - one dose of TOPV at birth and subsequent doses at 2, 4, and 9 months of age; or group B - one dose of TOPV at 2, 4 and 6 months of age. Blood samples were collected sequentially from the mother at delivery, from the umbilical cord, and from the child at 2, 4, 6, 9 and 12 months of age for assay of poliovirus neutralizing antibodies. Administration of TOPV at birth, in addition to establishing immunity against poliomyelitis at an earlier stage, produced a superior immune response to poliovirus type 3. At the end of the first year, the proportion of susceptible individuals was 3.7% in group A and 25.9% in group B. When immunization against poliomyelitis is started at birth, excellent seroconversion rates are obtained from the third dose onward.
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Bulletin Of The World Health Organization. Geneva 27: World Health Organization, v. 70, n. 1, p. 85-91, 1992.