SEQUENCING OF HEPARAN-SULFATE PROTEOGLYCANS - IDENTIFICATION OF VARIABLE AND CONSTANT OLIGOSACCHARIDE REGIONS IN 8 HEPARAN-SULFATE PROTEOGLYCANS OF DIFFERENT ORIGINS

SEQUENCING OF HEPARAN-SULFATE PROTEOGLYCANS - IDENTIFICATION OF VARIABLE AND CONSTANT OLIGOSACCHARIDE REGIONS IN 8 HEPARAN-SULFATE PROTEOGLYCANS OF DIFFERENT ORIGINS

Author Tersariol, Ivarne Luis dos Santos Autor UNIFESP Google Scholar
Ferreira, Thais Maria Paiva da Costa Autor UNIFESP Google Scholar
Medeiros, Maria das Gracas Liberato de Autor UNIFESP Google Scholar
Porcionatto, Marimélia Aparecida Autor UNIFESP Google Scholar
Moraes, Carlos Torres Autor UNIFESP Google Scholar
Abreu, Luiz Roberto Diz de Autor UNIFESP Google Scholar
Nader, Helena Bonciani Autor UNIFESP Google Scholar
Dietrich, Carl Peter Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract The sequence of the disaccharide units of eight heparan sulfate proteoglycans of different origins is described. All heparan sulfates contain 5 variable regions made of oligosaccharide blocks of disaccharides, namely, GlcUA(1-4)GlcNAc, GlcUA(1-4)GlcNS, IdoUA (1-4) GlcNS,6S, IdoUA-GlcNAc,6S, and IdoUA,2S(1-4)GlcNS,6S, besides two constant regions made of an internal tetrasaccharide (IdoUA-GlcNAc-IdoUA-GlcNS) and monosaccharides (GlcNS, and GlcNS,6S) at the non-reducing terminal. The N-acetylated region of the heparan sulfates is linked to the serine of the protein core through a trisaccharide of Xyl-Gal-Gal. Heparan sulfates differ from one another in terms of the number of disaccharides that compose each block.
Keywords HEPARAN SULFATE, STRUCTURE
HEPARAN SULFATE, OLIGOSACCHARIDE BLOCKS
HEPARAN SULFATE, SEQUENCING OF DISACCHARIDES
Language English
Date 1994-09-01
Published in Brazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 27, n. 9, p. 2097-2102, 1994.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Assoc Bras Divulg Cientifica
Extent 2097-2102
Access rights Closed access
Type Article
Web of Science ID WOS:A1994PG03900002
URI http://repositorio.unifesp.br/11600/43073

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