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dc.contributor.authorMimica, M. J.
dc.contributor.authorBerezin, Eitan Naaman [UNIFESP]
dc.contributor.authorCarvalho, R. L. B.
dc.contributor.authorMimica, I. M.
dc.contributor.authorMimica, L. M. J.
dc.contributor.authorSafadi, Marco Aurelio Palazzi [UNIFESP]
dc.contributor.authorSchneider, E.
dc.contributor.authorCaiaffa-Filho, H. H.
dc.identifier.citationBrazilian Journal Of Infectious Diseases. Salvador: Contexto, v. 11, n. 4, p. 415-417, 2007.
dc.description.abstractWe evaluated the performance of several methods for the detection of methicillin resistance in Staphylococcus aureus using 101 clinical S. aureus isolates from pediatric patients in a tertiary hospital in Brazil; 50 isolates were mecA-positive and 51 were mecA-negative. The Etest and oxacillin agar screening plates were 100% sensitive and specific for mecA presence. Oxacillin and cefoxitin disks gave sensitivities of 96 and 92%, respectively, and 98% specificity. Alterations of CLSI cefoxitin breakpoints increased sensitivity to 98%, without decreasing specificity. Our results highlight the importance of a continuing evaluation of the recommended microbiological methods by different laboratories and in different settings. If necessary, laboratories should use a second test before reporting a strain as susceptible, especially when testing strains isolated from invasive or serious infections. With the new (2007) CLSI breakpoints, the cefoxitin-disk test appears to be a good option for the detection of methicillin resistance in S. aureus.en
dc.relation.ispartofBrazilian Journal Of Infectious Diseases
dc.rightsAcesso aberto
dc.subjectdisc diffusionen
dc.titleDetection of methicillin resistance in Staphylococcus aureus isolated from pediatric patients: Is the cefoxitin disk diffusion test accurate enough?en
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionSanta Casa Univ Hosp
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.description.affiliationDept Pediat, Div Pediat Infect Dis, Sao Paulo, Brazil
dc.description.affiliationSanta Casa Univ Hosp, Dept Pathol, Microbiol Lab, Sao Paulo, Brazil
dc.description.affiliationFMUSP, Hosp Clin, LIM 03, Sao Paulo, Brazil
dc.description.sourceWeb of Science

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