Efeito da leucina na hipertrofia cardíaca e na concentração sérica de creatina quinase em ratos Wistar em hipertireoidismo experimental

Efeito da leucina na hipertrofia cardíaca e na concentração sérica de creatina quinase em ratos Wistar em hipertireoidismo experimental

Alternative title Effect of leucine in cardiac hypertrophy and serum creatine kinase in rats in experimental hyperthyroidism
Author Fidale, Thiago Montes Google Scholar
Goncalves, Alexandre Google Scholar
Paranhos Lopes, Leandro Teixeira Google Scholar
Alves, Poliana Rodrigues Google Scholar
Souza, Fernanda Rodrigues de Google Scholar
Dias Nunes, Joao Elias Google Scholar
Mundim, Antonio Vicente Google Scholar
Resende, Elmiro Santos Autor UNIFESP Google Scholar
Institution Universidade Federal de Uberlândia (UFU)
Universidade de Brasília (UnB)
Universidade Federal de São Paulo (UNIFESP)
Abstract Leucine is a regulator of protein metabolism in vivo, and there is little information regarding its action on cardiac hypertrophy induced by experimental hyperthyroidism and its relationship to serum creatine kinase. The study aimed to verify the effect of leucine in cardiac hypertrophy and serum creatine kinase in rats with hyperthyroidism. We used 20 animals were divided into four groups and these control, hormone, hormone + leucine and leucine. Hyperthyroidism was induced by administration of daily 20 mu g/100 grams of levothyroxine sodium in aqueous suspension by gavage. Leucine was supplemented by adding 5% of the amino conventional diet. Blood was collected by cardiac puncture and analyzes made in kit CK-NAC, CK-MB and TSH. At the end of the trial period of seven days the hearts were removed and weighed. Subsequently, the left ventricle was separated together with the interventricular septum and weighed. In statistical comparison was used analysis of variance (ANOVA) and two-way post-Tukey test, considering p values <0.05. Serum concentrations of serum CK-MB were lower in leucine (p <0.05) and hormone + leucine (p <0.05) compared to control. The hormone group, showed greater relative heart weight than the control group (p <0.05) and absolute heart weight greater than hormone + leucine (p <0.05). In conclusion, leucine appears to reduce cardiac hypertrophy and serum concentration of creatine kinase by unknown mechanisms.
Keywords Creatine kinase
Hyperthyroidism
Leucine
Infarction
Wistar
Language Portuguese
Date 2013-03-01
Published in Bioscience Journal. Uberlandia: Univ Federal Uberlandia, v. 29, n. 2, p. 499-505, 2013.
ISSN 1516-3725 (Sherpa/Romeo, impact factor)
Publisher Univ Federal Uberlandia
Extent 499-505
Origin http://www.seer.ufu.br/index.php/biosciencejournal/article/view/17649/12302
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000318222800027
URI http://repositorio.unifesp.br/11600/42840

Show full item record




File

Name: WOS000318222800027.pdf
Size: 142.7Kb
Format: PDF
Description:
Open file

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account