Efeitos em curto prazo da aplicação de aloxana para indução de diabetes em ratos Wistar

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Data
2010-05-01
Autores
Leme, Jose Alexandre Curiacos de Almeida
Castellar, Alexandre
Remedio, Rafael Neodini
Barbosa, Rodrigo Avelaira
Moura, Leandro Pereira de
Dalia, Rodrigo Augusto
Gomes, Ricardo José [UNIFESP]
Caetano, Flavio Henrique
Mello, Maria Alice Rostom de
Luciano, Eliete
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Artigo
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The present study aimed to verify action of alloxan in metabolic and immune parameters after 24 and 192 hours of the injection in Wistar rats. Thus, eight rats were fasted and received monohidrated alloxan Sigma (32 mg/kg body weight) via endovenous. Glycemia and trglyceridemia analyzes were performed before and 192 hours after alloxan application. After 24 hours, alloxan application increased water intake and decreased body mass, food intake and leucocytes counting. 192 hours after alloxan application, there was a recuperation in food intake and leucocytes counting. On the other hand, in this period there was an increase of glycemia and water intake and reduction of body mass. These results indicate that some of diabetic signs caused by alloxan occur in short-term after drug administration.
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Bioscience Journal. Uberlandia: Univ Federal Uberlandia, v. 26, n. 3, p. 442-447, 2010.
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