Avaliação da síntese intratecal de imunoglobulinas no transplante de medula óssea

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Data
1997-12-01
Autores
Almeida, Sergio Monteiro de [UNIFESP]
Livramento, Jose Antonio
Pasquini, Ricardo
Palou, Viviana Boccardi
Oliveira, Aparecido Mendes de
Doi, Elvira Missako
Ono, Margaret
Aso, Mirna Cigemi
Ferreira, Euripedes [UNIFESP]
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The central nervous system involvement in chronic graft versus host disease (GVHD) has been suggested. Chronic GVHD resembles auto immune connective tissue disorders. In order to investigate the immunoglobulin intra blood brain barrier (BBB) synthesis during chronic GVHD, and contribute to understanding the pathophysiology of the disease, we studied 33 patients who underwent allogeneic bone marrow transplants (BMT) from HLA identical related donors. Immunoglobulin intra BBB synthesis was investigated quantitative and qualitatively. The samples were collected pre BMT, pos BMT and during chronic GVHD. There were no evidence of immunoglobulin intra BBB synthesis, and no oligoclonal bands were found. Only isolated cases suggested IgG and IgA intra BBB synthesis, and in one case IgM during GVHD.
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Arquivos De Neuro-psiquiatria. Sao Paulo Sp: Assoc Arquivos De Neuro- Psiquiatria, v. 55, n. 4, p. 801-811, 1997.
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