MODIFICATIONS ON DOPAMINERGIC AND CHOLINERGIC SYSTEMS INDUCED BY THE WATER TANK TECHNIQUE - ANALYSIS THROUGH YAWNING BEHAVIOR

MODIFICATIONS ON DOPAMINERGIC AND CHOLINERGIC SYSTEMS INDUCED BY THE WATER TANK TECHNIQUE - ANALYSIS THROUGH YAWNING BEHAVIOR

Author Neumann, Beatrice Rosaura Guaragna Autor UNIFESP Google Scholar
Troncone, Lanfranco Ranieri Paolo Autor UNIFESP Google Scholar
Braz, S. Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Animals deprived of REM sleep by the water tank technique show an important decrease in frequency of yawning, induced by dopaminergic (apomorphine in low doses) and cholinergic (physostigmine and pilocarpine) agonists, if they are tested immediately after the 96 hr of deprivation. In order to understand the mechanisms underlying the effects of REM sleep deprivation on dopaminergic and cholinergic systems, we decided to test the animals after a recovery period of 24 hr. It was observed that apomorphine-induced yawning was still significantly reduced, whereas pilocarpine-induced yawning had returned to normal. The findings suggest that REM sleep deprivation alters dopaminergic and cholinergic systems in different ways: it seems that the interference on the dopaminergic system is prior and stronger than on the cholinergic system, thus its recovery demands more time.
Language English
Date 1990-11-01
Published in Archives Internationales De Pharmacodynamie Et De Therapie. Ghent: Arch Int Pharmacodynamie, v. 308, p. 32-38, 1990.
ISSN 0003-9780 (Sherpa/Romeo, impact factor)
Publisher Arch Int Pharmacodynamie
Extent 32-38
Access rights Closed access
Type Article
Web of Science ID WOS:A1990EZ51000004
URI http://repositorio.unifesp.br/11600/42633

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